CAS: 603139-19-1; (S)-N-(1-Cyanocyclopropyl)-4-Fluoro-4-Methyl-2-(((S)-2,2,2-Trifluoro-1-(4'-(Methylsulfonyl)-[1,1'-Biphenyl]-4-yl)Ethyl)Amino)Pentanamide

上下游产品

奥当卡替中间体3 (S)-4-Fluoro-4-Methyl-2-(((S)-2,2,2-Trifluoro-1-(4’-(Methylsulfonyl)-[1,1'-Biphenyl]-4-yl)Ethyl)Amino)Pentanoic Acid 875272-89-2

4,4'-二溴联苯置于正丁基锂,Sodium Tungstate (Vi) Dihydrate,双氧水,Potassium Carbonate,四正丁基硫酸铵,N,N-二异丙基乙胺,N-[(Dimethylamino)-3-Oxo-1H-1,2,3-Triazolo[4,5-B]Pyridin-1-Yl-Methylene]-N-Methylmethanaminium Hexafluorophosphate,Tri-N-Butyllithium Magnesate Complex体系中,用 四氢呋喃,甲醇,乙醚,正己烷,甲基叔丁基醚,N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应 45.0H,反应生成 奥当卡替
参考文献:奥当卡替及其中间体的制备方法
标题:奥当卡替及其中间体的制备方法
摘要:本发明公开了奥当卡替及其中间体的制备方法.本发明提供了一种三氟乙酮联苯甲砜中间体i的制备方法,包括以下步骤:溶剂中,在金属催化剂和无机碱的存在下,2,2,2‑三氟苯乙酮‑4‑硼酸频哪醇酯与4‑溴苯甲砜进行偶联反应,得到三氟乙酮联苯甲砜中间体i.本发明的制备方法,操作简单安全,路线步骤短,环境友好,反应收率高,制得的产品纯度高,而且以本发明的三氟乙酮联苯甲砜中间体i为中间体制得的奥当卡替ii,纯度高,符合原料药标准,适合于工业化生产.

专利信息

专利号:US-2018148745-A1
优先权日:2015-05-26
标题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor
发明人：ARNOLD FRANCIS H; RENATA HANS; MCINTOSH JOHN A; LEWIS RUSSELL D; KAN SEK BIK JENNIFER; HERNANDEZ KARI; COELHO PEDRO; ROZZELL DAVID; ZHANG CHEN
权利人:CALIFORNIA INST OF TECHN; PROVIVI INC
摘要:The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

专利号:US-9624478-B2
优先权日:2011-09-08
标题:Biocatalysts and methods for the synthesis of substituted lactams
发明人：CABIROL FABIEN LOUIS; CHEN HAIBIN; GOHEL ANUPAM; SALIM PAULINA ELENA; SMITH DEREK J; JANEY JACOB; KOSJEK BIRGIT; TANG WENG LIN; HSIEH HELEN; PHAM SON Q
权利人:CODEXIS INC
摘要:The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.

专利号:WO-2012163563-A1
优先权日:2011-05-31
标题:New strontium salts, synthesis and use thereof in the treatment of osteoporosis
发明人：MOURELLE MANCINI MARISABEL; DEL CASTILLO NIETO JUAN CARLOS
权利人:LACER SA; MOURELLE MANCINI MARISABEL; DEL CASTILLO NIETO JUAN CARLOS
摘要:The present invention relates to a strontium salt (I) wherein n is an integer which can take the values of 0 or 1 m is an integer which can take the values of 0 or 1 R is hydrogen or methyl and stereoisomers or hydrates thereof, to methods for its synthesis, and use in the treatment and/or prophylaxis of a cartilage and/or bone disease and/or conditions resulting in a dysregulation of cartilage and/or bone metabolism in a mammal.

专利号:US-2024358746-A1
优先权日:2022-05-03
标题 :Method of obtaining stable suspensions of heterocrystals of titanium dioxide or particles of silicon dioxide and stable suspensions obtained by this method for initiation of active form of oxygen in body at use in medical forms
发明人：KURKAYEV ABDULA
权利人:KURKAYEV ABDULA
摘要:The method of obtaining stable suspensions of heterocrystals of titanium dioxide and particles of silicon dioxide representing special class of quantum dots (QD). and stable suspensions obtained in such a way for initiation of active form of oxygen in the human body in use in medical forms. Starting material: Initial stuff in the form of aggregates with size more than 0.5 micrometer is mixed with an aqueous solution of pharmaceutical inorganic acid, with subsequent direction to homogenizing for the first stage of mixing, after that the obtained aqueous suspension is subjected to thermal treatment and, then aqueous suspension is directed to the rotary rotor-type evaporator periodically for evaporation of inorganic acid with suspension expense trough the rotor-type evaporator no more than 25 l/min and then the obtained activated particles are mixed with water in hydrodynamical cavitation-wave cavitational homogenizer to quasi-with regulated pulsating wave mode until obtaining stable suspension of heterocrystal of titanium dioxide or particles of silicon dioxide with size less than 450 nm, and presence on the lattice surface up to 60-80% of electronically-excited triplet oxygen 3+TO23O2 in the energy centers, namely, in the quantum dots—zones of local overheating, ensuring heat synthesis catalytic activity for formation of active forms of oxygen in the living organism human body.The surface of Stable suspension obtained by said method is characterized by distribution of activated crystals of titanium dioxide or with size up to 1 nm being 0.3 vol %, up to 20 nm being 5-40 vol %, particles with size up to 80 nm being 10-80 vol %, particles with size up to 150 nm being 5-30 vol %, particles with size up to 250 nm being 5-20 vol %, particles with size more than 250 nm-no more than 10 vol %, and distribution of activated particles of silicon dioxide with size 40-80 nm being 10-80 vol %, particles with size 80-150 nm being 10-80 vol %, particles with size 150-250 nm being less than 30 vol %, particles with size more than 250 nm—no more than 15%. The surface of heterocrystals of titanium dioxide and particles of silicon dioxide has sorption ability, that is an important factor for use in medical forms, ensuring detoxication of an organism, elimination of hypoxia, antiviral effect of a medical agent, antipathogenous effect in the body of living organism and elimination of under oxidation processes in the human body, increasing induction of immune response of vertebrata.

专利号:US-2023313155-A1
优先权日:2011-09-08
标题 :Biocatalysts and methods for the synthesis of substituted lactams

专利号:US-10858635-B2
优先权日:2011-09-08
标题 :Biocatalysts and methods for the synthesis of substituted lactams