CAS: 6938-06-3; Butyl Nicotinate

相似化合物

23597-82-2 614-18-6 20826-02-2

上下游产品

nicotinic acid butan-1-ol Pyridine-2,5-dicarboxylic acid pyridine-3-carbonyl chloride hydr°Chloride3-(butoxycarbonyl)-1-methylpyridinium iodide Nicotinic acid hydrazide

烟酸置于五氯化磷体系中,化学反应生成 烟酸丁酯
参考文献:Hukushima,Nippon Kagaku Kaishi/journal Of The Chemical Society Of Japan,1940,Vol. 61,P. 121,123
标题:Hukushima,Nippon Kagaku Kaishi/journal Of The Chemical Society Of Japan,1940,Vol. 61,P. 121,123

专利信息

专利号:US-9809567-B2
优先权日:2014-12-09
标 题:Synthesis and resolution of nicotine
发明人：WILLIS BERT; AHMED MOHAMMED MOINUDDIN; FREUND Wesley; SAWYER DOUGLAS
权利人:NJOY INC; NJOY LLC
摘要:The present disclosure generally relates to methods of preparing nicotine and resolving R,S nicotine to enrich the (S)(−) enantiomer. The method may comprise combining N-methyl-2-pyrrolidone or a salt thereof with a nicotinate compound in the presence of a solvent and a strong base to form 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof; and reducing the 1-methyl-3-nicotinoyl-2-pyrrolidone or salt thereof in solution with Na 2 S 2 O 4 to produce racemic nicotine or salt thereof. Resolving the racemic nicotine (or other enantiomeric mixture) may comprise combining the nicotine with (−)-O,O′-di-p-toluoyl-L-tartaric acid (L-PTTA).

专利号:US-5278337-A
优先权日:1992-10-14
标 题:Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
发明人：MANIMARAN THANIKAVELU; STAHLY G PATRICK; HERNDON JR R CARL
权利人:ETHYL CORP
摘要:A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties: n 1) has at least one eutectic point; n 2) a composition that is not at the eutectic point; and n 3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid. n Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.

专利号:US-2019263777-A1
优先权日:2014-12-09
标 题 :Synthesis and resolution of nicotine

专利号:US-5248813-A
优先权日:1992-10-14
标题:Enantiomeric resolution
发明人：MANIMARAN THANIKAVELU; STAHLY G PATRICK; HERNDON JR R CARL
权利人:ETHYL CORP
摘要:A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties: n (1) has at least one eutectic point; n (2) a composition that is not at the eutectic point; and n (3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid. n Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.

专利号:US-2016326134-A1
优先权日:2014-12-09
标题:Synthesis and resolution of nicotine

专利号:US-10329271-B2
优先权日:2014-12-09
标题:Synthesis and resolution of nicotine