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CAS号107-05-1 氯丙烯 | CAS号23973-51-5 硫代乙酸烯丙酯 | CAS号106-95-6 烯丙基溴 | CAS号2179-57-9 二烯丙基二硫醚 | CAS号107-18-6 烯丙醇 | CAS号539-86-6 大蒜素 | CAS号83318-98-3 2-methylsulfany... | CAS号4396-19-4 ethylsulfanylme... | CAS号34135-85-8 甲基烯丙基三硫醚 | CAS号5296-62-8 烯丙基乙基巯醚 | CAS号22842-59-7 Propanal,3-(2-p... | CAS号629-19-6 二丙基二硫 | CAS号874-14-6 1,3-二甲基尿嘧啶 | CAS号120289-80-7 1,3-dimethyl-5-... | CAS号2444-49-7 二烯丙基四硫醚 | CAS号27817-67-0 烯丙基二硫化物

大蒜素置于谷胱甘肽体系中,化学反应生成 烯丙硫醇
参考文献:大蒜素和烯丙基混合二硫化物与蛋白质和硫醇小分子的反应机理
标题:大蒜素和烯丙基混合二硫化物与蛋白质和硫醇小分子的反应机理
摘要:大蒜中的烯丙基硫化物是化学预防剂.预期进入的细胞最初会与谷胱甘肽相互作用.因此,在无细胞系统中分析了产物s-烯丙基硫代谷胱甘肽与模型蛋白和硫醇的反应机理.以谷胱甘肽,半胱氨酰基或卡托普利代表s-烯丙基脂族加合物,与巯基的反应产生由s-烯丙基和脂族部分两者形成的混合二硫化物混合物. 为了改善常规的血压前药治疗,癌症和肠道炎症合成了s-烯丙基硫代前药,例如s-烯丙基硫代6-巯基嘌呤和s-烯丙基硫代-卡托普利.2种成分的协同活性以及增加的细胞渗透性允许有效的体内活性.这些衍生物与谷胱甘肽反应后,形成s-烯丙基硫代-谷胱甘肽,而6-巯基嘌呤为离去基团.过量的细胞谷胱甘肽使巯基-二硫键交换反应发生数个周期,从而扩展了杂合药物的药效学.
DOI:10.1016/j.Ejmech.2010.01.031

专利信息

专利号:US-11866398-B2
优先权日:2018-05-15
标 题:Total synthesis of prostaglandin J natural products by stereoretentive metathesis
发明人：LI JIAMING; CHEN XU; AHMED TONIA S; STOLTZ BRIAN M; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

专利号:US-10995049-B2
优先权日:2019-07-19
标 题 :Total synthesis of prostaglandin J natural products and their intermediates
发明人：LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-4158673-A
优先权日:1976-10-11
标 题 :Process for the synthesis of bis(alkyl sulphide)-decaborane (12)
发明人：DAZORD JACQUES L; MONGEOT HENRI M; GUILLEVIC GILDAS J; CUEILLERON JEAN F
权利人:FRANCE ETAT
摘要:The invention relates to a process for the synthesis of bis(alkyl sulphide)-decaboranes (12). n This synthesis is characterized in that a decahydrodecaborate (2-) salt of the general formula M 2 B 10 H 10 , in which M represents a positive radical, is treated with a mixture comprising a strong oxygen-containing acid and an alkyl sulphide of the formula R 2 S, in which R is a lower alkyl radical. In a preferred procedure, the said mixture is a solution of a strong oxygen-containing acid which is saturated with an alkyl sulphide. n The bis(alkyl sulphide)-decaboranes (12) are especially useful in the synthesis of certain carboranes.

专利号:US-7534906-B2
优先权日:2002-06-28
标 题:Process for the synthesis of hydrogenofluoromethylenesulphonyl radical derivatives
发明人：SAINT-JALMES LAURENT
权利人:RHODIA CHIMIE SA
摘要:The invention concerns a method for synthesis of hydrogenofluoromethylenesulphonyl radical derivatives, comprising: a) a step which consists in condensing a thiolate (that is a monoalkyl sulphide salt) with a compound having a sp; 3hybridized carbon bearing a hydrogen, a fluorine, a heavy halogen selected among chlorine, bromine and iodine and an electron-attracting group selected among fluorine and those whereof the; is not less than 0.2, advantageously than 0.4; b) a step which consists in oxidizing the compound obtained in step a). The invention is applicable to the synthesis of various compounds having a suphinyl or sulphonyl group.

专利号:US-2008086013-A1
优先权日:2006-06-15
标 题:Carbometallation of alkynes and improved synthesis of uniquinones
发明人：LIPSHUTZ BRUCE H
权利人:UNIV CALIFORNIA
摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.