CAS: 102-27-2; N-Ethyl-3-Methylaniline

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CAS号108-44-1 3-甲基苯胺 | CAS号75-05-8 乙腈 | CAS号99-08-1 3-硝基甲苯 | CAS号537-92-8 N-乙酰基-3-甲苯胺 | CAS号4735-73-3 N-ethyl-3-methy... | CAS号64-17-5 乙醇 | CAS号111-34-2 乙烯基正丁醚 | CAS号54509-73-8 ethene | CAS号109-92-2 乙烯基乙醚 | CAS号74-96-4 溴乙烷 | CAS号91-88-3 N-乙基-N-羟乙基间甲苯胺 | CAS号2498-02-4 N-[2-(N-ethyl-m... | CAS号82692-93-1 N-乙基-N-(2-羟基-3-... | CAS号22564-43-8 N-乙基-N-氯乙基-3-甲基苯胺 | CAS号5856-00-8 N-(4-氨基-3-甲基苯基)... | CAS号19248-13-6 N-(2-氨乙基)-N-乙基间甲苯胺 | CAS号36783-03-6 N-乙基-N-磺丙基间甲苯胺 | CAS号75489-04-2 3-[2-(4-amino-3... | CAS号77778-48-4 7-bromo-10-ethy... | CAS号6923-65-5 sodium 2-[ethyl...

3-甲基苯胺置于dimethyl Sulfide Borane体系中,用 四氢呋喃 用作溶剂,化学反应 27.0H,反应生成N-乙基间甲苯胺
参考文献:具有双重雌激素受体α降解和组蛋白脱乙酰酶抑制活性的新型混合偶联物用于乳腺癌治疗
标题:具有双重雌激素受体α降解和组蛋白脱乙酰酶抑制活性的新型混合偶联物用于乳腺癌治疗
摘要:以雌激素受体为靶点的激素疗法在临床上广泛用于治疗乳腺癌,如他莫昔芬,但多为部分激动剂,长期使用会引起严重的副作用.选择性雌激素受体下调剂 (Serd) 的使用可能是乳腺癌治疗的有效替代方案,通过直接降解 Erα 蛋白来关闭 Erα 信号传导.然而,临床上单独使用的serd氟维司群,口服生物利用度低,需要静脉注射,严重限制了其临床应用.另一方面,双靶点或多靶点偶联物能够通过不同途径协同抗肿瘤活性,因此与单一靶向治疗相比可以提高治疗效果.在这项研究中,我们通过将特权 Serd 骨架 7-氧杂双环 [2.2.1] 庚烷磺酰胺 (Obhsa) 与组蛋白脱乙酰酶抑制剂侧链相结合,设计并合成了一系列针对 Erα 降解和组蛋白脱乙酰酶抑制的新型双功能偶联物.我们发现obhsa单元的磺酰胺氮和苯基上的取代基对生物活性有显着影响.其中,共轭具有n-甲基和萘基的16I对 Mcf-7 细胞表现出有效的抗增殖活性,以及优异的
Doi:10.1016/j.Bmc.2021.116185

专利信息

专利号:US-9856205-B2
优先权日:2011-09-28
标 题:Method for the selective production of N-methyl-para-anisidine
发明人：IVANOV YURIY ALEXANDROVICH; BELIAKOV NIKOLAY GRIGORIEVICH
权利人:IVANOV YURIY ALEXANDROVICH; FROLOV ALEXANDER YURIEVICH; BELIAKOV NIKOLAY GRIGORIEVICH; IFOTOP LLC
摘要:The invention “Method for selective synthesis of N-methyl-para-anisidineâ€? relates to chemical technology processes, namely to catalytic alkylation of aromatic amines and nitro compounds. n The invention relates to the method for synthesis of N-methyl-para-anisidine (N-methyl-para-methoxyaniline; N-methyl-para-amino anisole) from para-anisidine (para-amino anisole; para-methoxyaniline) or para-nitro anisole (1-methoxy-4-nitrobenzene) and methanol in the presence of hydrogen or without hydrogen on heterogeneous catalyst. n Proposed method permits to use existing process plants used for obtaining aniline and 14-methylaniline. n The invention purpose is to provide the possibility to produce N-methyl-para-anisidine with purity at least 98% and high output that allows arrangement of highly profitable industry-scale manufacturing process.

专利号:US-4658009-A
优先权日:1985-03-14
标题:Novel 2-substituted-4,6-diamino-s-triazine/isocyanuric acid adduct, process for synthesis of said adduct and process for curing polyepoxy resin with said adduct
发明人：KAMAGATA KAZUO; YAMADA TOSHIAKI; SAWA NATSUO
权利人:SHIKOKU CHEM
摘要:Disclosed is a 2-substituted-4,6-diamino-s-triazine/isocyanuric acid adduct represented by the following formula: (1) wherein R stands for an alkyl group having 2 to 20 carbon atoms, an unsubstituted or cyano group-substituted aryl group, or a group of the formula R1-CH2CH2- in which R1 stands for an alkoxy group having up to 20 carbon atoms, an acyloxy group, an amino group, an N-substituted amino group, a benzotriazolyl group or a 2-alkylimidazolyl-(4)-dithiocarbonyl group, or by the following formula: (2) wherein R2 stands for an alkylene group which may have an intervening imino or phenylene group. When this adduct is used for curing a polyepoxy resin, a cured product having good heat resistance, insulating property and adhesion and an excellent migration-preventing effect is formed.

专利号:US-4719053-A
优先权日:1980-08-01
标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates
发明人：SCHLAEFER LUDWIG; HAEHNLE REINHARD
权利人:HOECHST AG
摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.

专利号:JP-S6078946-A
优先权日:1983-09-09
标题 :Continuous method for the synthesis of asymmetric, substituted diphenylamines

专利号:CN-100408179-C
优先权日:2005-05-20
标 题:Transition metal catalyst for gas phase synthesis of N-alkylaniline by aniline and alcohol

专利号:EP-0194895-A2
优先权日:1985-03-14
标题 :2-substituted-4, 6-diamino-s-triazine/isocyanuric acid adduct, process for synthesis of said adduct and process for curing polyepoxy resin with said adduct