CAS: 106291-80-9; Methyl 4-Bromo-3-Hydroxybenzoate

相似化合物

14348-38-0 2737-19-1 20035-32-9

上下游产品

methanol 4-bromo-3-hydroxybenzoic acid methyl 3-hydroxybenzoate 3-Carboxyphenolmethyl 4-bromo-3-methoxybenzoate 4-bromo-3-[2-(2,4-dichloro-phenyl)-ethoxy]-benzoic acid methyl ester methyl 4-bromo-3-(tetrahydropyran-2-yloxy)benzoate 4-bromo-3-(tetrahydropyran-2-yloxy)benzyl alcohol

间羟基苯甲酸置于硫酸,溴,溶剂黄146体系中,用 甲醇,乙醇 用作溶剂,化学反应 16.5H,反应生成4-溴-3-羟基苯甲酸甲酯
参考文献:Elongated And Substituted Triazine-Based Tricarboxylic Acid Linkers For Mofs
标题:Elongated And Substituted Triazine-Based Tricarboxylic Acid Linkers For Mofs
摘要:基于新三嗪基三羧酸连接剂的研究成果作为三嗪三苯甲酸(tatb)的延伸衍生物而制备.此外,引入了功能基团(no2,Nh2,Ome,Oh)以便进行mofs的潜在后合成修饰(psm).通过不对称三聚物化反应,将一个酸氯化物(ome或no2取代)与两当量未取代的腈混合,得到功能化的三(4-溴芳基)三嗪"核心"(3A,3B).将核心3与适当的苯基和联苯基硼酸衍生物进行三次铃木偶联反应,得到延伸的三羧酸连接剂,即羧酸17和20或它们的酯16和19.还对硝基基团进行还原并裂解甲氧基团,得到相应的氨基和羟基取代的三嗪连接剂.
Doi:10.3762/bjoc.12.219

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-7807709-B2
优先权日:2005-03-23
标题 :Organic compounds
发明人：EHRHARDT CLAUS; IRIE OSAMU; LORTHIOIS EDWIGE LILIANE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER
权利人:NOVARTIS AG
摘要:The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis.