CAS: 1072-71-5; 2,5-Dimercapto-1,3,4-Thiadiazole

上下游产品

carbon disulfide H-[1,3,4]thiadiazole-2-thione5-ethoxycarbonylmercapto-3H-[1,3,4]thiadiazole-2-thione bis-thiohydrazin°Carbonyl-sulfane formic acid hydrazideH-[1,3,4]thiadiazole-2-thione5-phenethylmercapto-3H-[1,3,4]thiadiazole-2-thione bis-phenethylmercapto-[1,3,4]thiadiazole H-[1,3,4]thiadiazole-2-thione5-ethylsulfanyl-3H-[1,3,4]thiadiazole-2-thione H,3'H-5,5'-sulfanediyl-bis-[1,3,4]thiadiazole-2-thione3H,3'H-5,5'-sulfanediyl-bis-[1,3,4]thiadiazole-2-thione

二硫化碳置于一水合肼体系中,用 乙醇,氨 用作溶剂,化学反应 1.0H,以62%的收率获得2,5-二巯基噻二唑
参考文献:Dipolar Cycloaddition Reactions Of Nitrilimines
标题:Dipolar Cycloaddition Reactions Of Nitrilimines
摘要:一系列γ-取代的α-亚甲基-γ-丁内酯 衍生物与 N-甲基-C-苯基-Nitriline(n-甲基-C-苯基-Nitriline)进行了 1,3-二极环加成反应. N-Methyl-C-Phenylnitrilimine 进行 1,3-二极环加成反应. 这些反应以高非对映选择性和区域特异性进行 非对映选择性,通常有利于反 非对映异构体. 轨道计算所确定的.一种产物的分配得到了 X 射线 晶体学. N-甲基-C-苯基硝基亚胺 与一系列含 C=s 的二极性化合物发生了特定的环加成反应. 二极性.取代的硫脲类化合物作为二极亲和剂一般没有反应. 二极亲和剂,而 5-硫代 1,3,4-噻二唑-2(3H)-亚硫酸盐则会立即发生反应,产生 反应,产生复杂的重排产物,而不是预期的环载产物. 产物.其中一种不寻常产物的结构已通过 X 射线晶体学.一系列二取代的次氮基亚胺基进行了 与硫代二苯甲酮发生了特定的环加成反应;X 射线晶体学证实了这些产物的结构. X 射线晶体学证实了这些产物的结构.
Doi:10.1071/c97157

专利信息

专利号:US-2024262834-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof
发明人：CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

专利号:US-5177235-A
优先权日:1992-06-11
标题 :Synthesis of tetraalkylsilanes
发明人：EISENBERG DAVID C; ROBINSON GENE C
权利人:ETHYL CORP
摘要:This invention relates to a process for preparing tetrahydrocarbylsilane in high yield, comprising: a) forming a reaction mass from molten metal and trihydrocarbylaluminum, in an hydrocarbon solvent under an inert gas atmosphere; b) maintaining the reaction mass at a temperature in the range of from about 100° to about 130° C. for a period of time sufficient to form sodium tetrahydrocarbylaluminate; c) contacting the sodium tetrahydrocarbylaluminate with organotrihalosilane; and d) heating the contacted tetrahydrocarbylaluminate and organotrihalosilane to a temperature and for a period of time sufficient to form the tetrahydrocarbylsilane, wherein the tetrahydrocarbylaluminate and tetrahydrocarbylsilane are formed at a pressure of less than about 3000 KPa and wherein the hydrocarbyl group of the tetrahydrocarbyl silane is one or a mixture of hydrocarbyl groups having less than about 8 carbon atoms each.

专利号:US-5247061-A
优先权日:1992-07-22
标题 :Synthesis of poly(dithio thiadiazole by oxidative polymerization
发明人：ZISMAN STAN A; WILLIAMS RALPH P
权利人:PHILLIPS PETROLEUM CO
摘要:This invention relates to the preparation of poly(dithio thiadiazole) by combining an oxidizing agent, a dithio thiadiazole, and an aprotic polar solvent thereby producing a polymer precipitant which may then be washed to remove residual contaminants.

专利号:US-10557210-B2
优先权日:2014-02-24
标题 :Direct electrochemical synthesis of doped conductive polymers on metal alloys
发明人：KINLEN PATRICK JOHN; LAWLESS LAWRENCE MICHAEL
权利人:BOEING CO
摘要:This disclosure relates generally to the discovery of improved methods of reducing corrosion on metals and metal alloys without using hexavalent chromium reagents. More particularly, the disclosure relates to preparing corrosion resistant metals using doped conducting polymers such as polyaniline (PANI) on metal alloys such as aluminum alloys.

专利号:WO-2024256666-A1
优先权日:2023-06-16
标 题:Production of synthesis gas by partial oxidation of a hydrocarbon stream containing plastic liquefaction oil
发明人：ADAM CINDY; CHOFFAT ALEXANDRINE; MINOUX DELPHINE; VAN LOOK EMMANUEL; BRETON CHRISTOPHE
权利人:TOTALENERGIES ONETECH
摘要:The invention relates to a process for the production of synthesis gas by partial oxidation from a hydrocarbon stream containing plastic liquefaction oil, comprising: a) providing a composition stabilized against premature polymerization comprising: 1) a hydrocarbon stream containing at least 2 wt% of plastic liquefaction oil which is containing contaminants, the remaining part of said hydrocarbon stream being a diluent, 2) at least one additive capable to reduce gums formation or buildup, 3) optionally at least one additive which is a dispersant agent, b) an optional purification step to trap silicon and/or metals and/or phosphorous and/or halogenates over at least one trap to obtain a purified composition, c) gasifying by partial oxidation the stabilized composition provided in step (a), or the purified composition provided in step (b), in a partial oxidation gasification unit to produce synthesis gas comprising at least dihydrogen, carbon monoxide, and carbon dioxide.

专利号:US-12007376-B2
优先权日:2014-02-26
标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample
发明人：LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M
权利人:TRACE ABILITY INC
摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.