CAS: 14014-06-3; Sodium Deuteroxide (D)

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CAS号7789-20-0 重水 | CAS号7440-23-5 钠标准溶液 | CAS号7789-20-0 重水

重水置于sodium体系中,用 甲苯 用作溶剂,化学反应生成氘氧化钠
参考文献:Lahti,Markku,Acta Chemica Scandinavica. Series A: Physical And Inorganic Chemistry,1987,Vol. 41,P. 93-97
标题:Lahti,Markku,Acta Chemica Scandinavica. Series A: Physical And Inorganic Chemistry,1987,Vol. 41,P. 93-97

专利信息

专利号:US-11613514-B2
优先权日:2016-03-25
标题:Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine
发明人：THOMAS CRAIG; ZARATE CARLOS; MOADDEL RUIN; GOULD TODD; ZANOS PANOS; MORRIS PATRICK
权利人:US HEALTH; UNIV MARYLAND
摘要:The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.

专利号:US-2014046064-A1
优先权日:2010-12-03
标题:Process for the Synthesis of Precursor Complexes of Titanium Dioxide Sensitization Dyes Based on Ruthenium Polypyridine Complexes
发明人：BOARETTO RITA; BUSATTO EVE; CARLI STEFANO; FRACASSO SANDRO; CARAMORI STEFANO; BIGNOZZI CARLO ALBERTO
权利人:DYEPOWER
摘要:The present invention concerns a process for the synthesis of precursor complexes and titanium dioxide sensitizing dyes based on ruthenium polypyridine complexes comprising the microwave irradiation under high pressure and in aqueous environment system of precursor complexes and sensitizers based on carboxylic functionalized ruthenium polypyridine complexes

专利号:US-5247099-A
优先权日:1989-08-17
标题:Process for synthesis of 7-hydroxy coumarins having substitutions in the 4-position
发明人：CELEBUSKI JOSEPH E
权利人:ABBOTT LAB
摘要:A process for synthesis of a compound of the formula: said process comprising the steps of (a) reacting 4-bromomethyl-7-methoxy coumarin with a malonic ester under conditions sufficient to achieve condensation of the ester to give the monoalkylated (2-bis(carbalkoxy)-2-R1-1-ethyl) derivative; (b) removing one of the carbalkoxy groups from the product of step (a); (c) demethylation of the product of step (b) to give the 7-hydroxycoumarin compound; and (d) chemically modifying the remaining ester to yield a desired R2.

专利号:US-2015361267-A1
优先权日:2010-12-03
标 题:Process for the Synthesis of Precursor Complexes of Titanium Dioxide Sensitization Dyes Based on Ruthenium Polypyridine Complexes
发明人：BOARETTO RITA; BUSATTO EVA; CARLI STEFANO; FRACASSO SANDRO; CARAMORI STEFANO; BIGNOZZI CARLO ALBERTO
权利人:DYEPOWER
摘要:The present invention concerns a process for the synthesis of both precursor complexes and dye sensitizers for titanium dioxide based on ruthenium polypyridine complexes comprising microwave irradiation, under high pressure and in aqueous environment system

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:US-2004101523-A1
优先权日:1989-07-27
标题:Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension
发明人：REITZ DAVID B; KOEPKE JOHN P; BLAINE EDWARD H; SCHUH JOSEPH R; MANNING ROBERT E; SMITS GLENN J
权利人:SEARLE & CO
摘要:Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are derived from inhibitor compounds capable of inhibiting one or more of the enzymes involved in catecholamine synthesis, such compounds being classifiable as tyrosine hydroxylase inhibitors, or as dopa-decarboxylase inhibitors, or as dopamine-β-hydroxylase inhibitors. These inhibitor compounds are linked to a chemical moiety, such as a glutamic acid derivative, by a cleavable bond which is recognized selectively by enzymes located predominantly in the kidney. The liberated inhibitor compound is then available in the kidney to inhibit one or more of the enzymes involved in catecholamine synthesis. Inhibition of renal catecholamine synthesis can suppress heightened renal nerve activity associated with sodium-retention related disorders such as hypertension. Conjugates of particular interest are glutamyl derivatives of dopamine-β-hydroxylase inhibitors, of which N-acetyl-γ-glutamyl fusaric acid hydrazide (shown below) is preferred.