十九烷酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应 1.0H,以83%的收率获得十九烷醇 参考文献:The Synthesis Of A Single Enantiomer Of A Major α-Mycolic Acid Of M. Tuberculosis 标题:The Synthesis Of A Single Enantiomer Of A Major α-Mycolic Acid Of M. Tuberculosis 摘要:We Report A Synthesis Of A Single Enantionner Of A Mycolic Acid From Mycobacterium Tuberculosis Containing A Di-Cis-Cyclopropane. The Method Can Be Simply Varied To Modify The Chain Lengths Or The Absolute Stereochemistry Of Either Cyclopropane. (C) 2005 Elsevier Ltd. All Fights Reserved. Doi:10.1016/j.Tet.2005.09.056
专利号:US-10730904-B2 优先权日:2012-11-14 标 题:Method for liquid-phase synthesis of nucleic acid 发明人:NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO 权利人:TAKEDA PHARMACEUTICALS CO 摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.
专利号:US-6262251-B1 优先权日:1995-10-19 标题 :Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING 权利人:PROLIGO LLC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
专利号:US-4219684-A 优先权日:1979-04-02 标 题 :Synthesis of alcohols by hydroformylation with nitrile promoter 发明人:IMAI TAMOTSU 权利人:UOP INC 摘要:Alcohols may be synthesized by reacting an olefinic compound, carbon monoxide and hydrogen in the presence of a Group VIII organometallic complex catalyst at reaction conditions which include a temperature in the range of from about 50° to about 250° C. and a pressure in the range of from about 10 to about 300 atmospheres. In addition, the reaction is also effected in the presence of a promoter compound comprising a nitrile.
专利号:US-4356334-A 优先权日:1979-05-16 标题 :Synthesis of alcohols 发明人:IMAI TAMOTSU 权利人:UOP INC 摘要:Alcohols may be synthesized by reacting an olefinic hydrocarbon, carbon monoxide, and hydrogen in the presence of a catalyst comprising a rhodium carbonyl or organohodium complex and a promoter comprising ammonia at temperatures in the range of from about 50° to about 250° C. and a pressure in the range of from about 10 to about 300 atmospheres to produce the desired alcohol.
专利号:US-9006347-B2 优先权日:2011-09-08 标 题 :Method of synthesising polycarbonates in the presence of a bimetallic catalyst and a chain transfer agent 发明人:WILLIAMS CHARLOTTE K; KEMBER MICHAEL; BUCHARD ANTOINE; JUTZ FABIAN 权利人:IMP INNOVATIONS LTD 摘要:The invention provides a process for the synthesis of a polycarbonate, the process comprising the step of reacting carbon dioxide with at least one epoxide in the presence of a catalyst of formula (I) and a chain transfer agent. The invention also provides a polymerization system for the copolymerization of carbon dioxide and at least one epoxide comprising a catalyst of formula (I) and a chain transfer agent, polycarbonates produced by the inventive process, a block copolymer comprising a polycarbonate produced by the inventive process, and a method of producing the block copolymer. The invention also relates to novel catalysts of formula (III).
专利号:US-8178585-B2 优先权日:2007-11-14 标题 :Solvent-free synthesis of soluble nanocrystals 发明人:PETRUSKA MELISSA; PAN GUIQUAN 权利人:PETRUSKA MELISSA; PAN GUIQUAN; ADVANCED TECH MATERIALS 摘要:Methods for preparing high quality and high yields of nanocrystals, i.e., metal-oxide-based nanocrystals, using a novel solvent-free method. The nanocrystals advantageously comprise organic alkyl chain capping groups and are stable in air and in nonpolar solvents.
[参考文献]: D'Auria M, Et, Al. The Scent Of Neotinea Orchids From Basilicata (Southern Italy). Nat Prod Res. 2021 Jan 19;1-3. [参考文献]: Guleria S, Et, Al. Composition And Antimicrobial Activity Of The Essential Oil Of Heracleum Thomsonii (Clarke) From The Cold Desert Of The Western Himalayas. Nat Prod Res. 2011 Aug;25(13):1250-60. [参考文献]: Daniela F S Fonseca, Et Al. Bioactive Phytochemicals From Wild Arbutus Unedo L. Berries From Different Locations In Portugal: Quantification Of Lipophilic Components. Int J Mol Sci. 2015 Jun 23;16(6):14194-209.
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 参考文献:10.1021/jp7112208 摘要:Zobrist B, Marcolli C, Peter T, Koop T. Heterogeneous ice nucleation in aqueous solutions: the role of water activity. J Phys Chem A. 2008 May 01;112(17):3965–75. doi: 10.1021/jp7112208.