CAS: 2749-11-3; (S)-2-Aminopropan-1-Ol

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106391-86-0 147252-84-4 161529-13-1

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CAS号56-41-7 L-丙氨酸 | CAS号10065-72-2 3-酞酰亚胺基丙酸甲酯 | CAS号3913-67-5 N-甲基-L-丙氨酸 | CAS号2885-02-1 (S)-2-氨基丙酸丁酯 | CAS号485-47-2 茚三酮 | CAS号2491-20-5 L-丙氨酸甲酯盐酸盐 | CAS号6003-05-0 L-丙氨酸盐酸盐 | CAS号374783-78-5 (S)-2-甲基-1-(4-硝... | CAS号1178001-75-6 (S)-N-(1-hydrox... | CAS号501-52-0 3-苯丙酸 | CAS号3274-53-1 3,5-dimethyl-2-... | CAS号93-54-9 1-苯基-1-丙醇 | CAS号79069-13-9 N-B°C-L-丙氨醇 | CAS号6940-80-3 N-苄基丙氨醇 | CAS号52340-20-2 (S)-2-甲基氮丙啶 | CAS号60479-65-4 (S)-(+)-2-(二苄氨基... | CAS号128648-99-7 3-羟基丙脒

(S)-((2-Azidopropoxy)Methyl)Benzene置于10 Wt% Pd(Oh)2 On Carbon,氢气,三氟乙酸体系中,用 甲醇 用作溶剂,化学反应 8.0H,反应生成L-氨基丙醇
参考文献: An Improved Synthesis Of Anti-Parkinson Agent[fr] Synthèse Améliorée D'Agent Antiparkinsonien
标题: An Improved Synthesis Of Anti-Parkinson Agent[fr] Synthèse Améliorée D'Agent Antiparkinsonien
摘要:本发明涉及一种改进的合成抗帕金森化合物的方法,该化合物的化学式为(i),可从商业上可获得的(R)-苄基环氧乙烷合成,其中所得化合物的对映纯度大于98%.化学式(i)中,R1和r2各自独立地选自氢或卤素.

专利信息

专利号:US-9139515-B2
优先权日:2011-08-19
标 题:Synthesis of R-biphenylalaninol
发明人：HERMSEN PETRUS JOHANNES; ERMANN PETER HANS; RIEBEL PETER HANS; WOLBERG MICHAEL; DE VRIES ANDREAS HENDRIKUS MARIA
权利人:HERMSEN PETRUS JOHANNES; ERMANN PETER HANS; RIEBEL PETER HANS; WOLBERG MICHAEL; DE VRIES ANDREAS HENDRIKUS MARIA; DPX HOLDINGS BV
摘要:This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The invention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-5869725-A
优先权日:1994-05-17
标 题:Derivatives of aminosulfonic acids, utilization of the same in the synthesis of pseudopeptides and process for their preparation
发明人：GENNARI CESARE; POTENZA DONATELLA; SALOM BARBARA
权利人:PHARMACIA & UPJOHN SPA
摘要:Derivatives of gamma-amino-alpha,beta-unsaturated sulfonic acids, a process for the preparation of the same and their utilization in the synthesis of pseudopeptides characterized by the presence of at least a sulfonamide type bond conjugated to a double bond are described.

专利号:US-2006058532-A1
优先权日:2004-09-10
标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
发明人：CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.

专利号:US-8440844-B2
优先权日:2011-06-21
标题 :Process for the preparation of β-amino alcohol
发明人：RAWAT VARUN; CHOUTHAIWALE PANDURANG VILASRAO; CHAVAN VILAS BHIKU; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM
权利人:RAWAT VARUN; CHOUTHAIWALE PANDURANG VILASRAO; CHAVAN VILAS BHIKU; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM; COUNCIL SCIENT IND RES
摘要:A high-yielding enantioselective synthesis of the bioactive (S)—N-(5-chlorothiophene-2-sulfonyl)-β,β-diethylalaniol (7.b.2), a Notch-1-sparing γ-secretase inhibitor metabolite (with EC 50 =28 nM) effective in reduction of Aβ production in vivo, has been realized starting from readily available 3-pentanone. The key steps of the synthesis are proline-catalyzed α-aminooxylation and α-amination of aldehyde; the latter contributing an overall yield of 50-75% and 90-99% enantiomeric excess.

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.