CAS: 4704-77-2; 3-Bromopropane-1,2-Diol

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137490-63-2 14437-88-8 148173-18-6

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烯丙醇置于2,4,6-三溴-1,3,5-三嗪,N-甲基吗啉氧化物体系中,用 氯仿 作为反应溶剂,以85%的收率获得产物3-溴-1,2-并二酚
参考文献:研究成的反应ñ-Methylmorpholine-ñ与氰尿酰氯氧化物(nmmo)及其水合物
标题:研究成的反应ñ-Methylmorpholine-ñ与氰尿酰氯氧化物(nmmo)及其水合物
摘要:N-甲基吗啉-N-氧化物(nmmo,1A)与氰尿酰氯(2)之间的反应过程严格取决于氧化胺的水合物水含量.在固相中,两种物质都会发生爆炸状的极度放热反应.在溶液中,此过程变得可控,并导致nmmo定量降解为吗啉和甲醛,其中2仅用作诱导剂.该反应可以以实现干净的脱氧脱甲基的方式进行.nmmo(1B)的一水合物在2的作用下定量转化为n-甲基吗啉和次氯酸..该转化可用于合成中以使叔胺n-氧化物一水合物脱氧,或在非水有机介质中以较高的收率生产氯醇.nmmo(1C)的半半水合物在消耗水的情况下与2反应,直到存在非水合的nmmo,然后将其进一步转化为吗啉和hcho,就像将1A直接用作起始原料一样.
DOI:10.1016/s0040-4020(02)01291-7

专利信息

专利号:US-2007049637-A1
优先权日:2003-11-12
标 题:Process for the synthesis of cationic lipids
发明人：DE FERRA LORENZO; ANIBALDI MAURO; AMMIRATI ETTORE
权利人:CHEMI SPA
摘要:A process for the synthesis of lipid cations having general formula (6): n n nin which: R 1 represents a lipophilic chain; R 2 , R 3 , R 4 , which are identical or different from one another, represent C 1 -C 10 alkyl, C 1 -C 10 alkenyl, or C 1 -C 10 alkynyl radicals, optionally containing hydroxyl, ether, halogen and acyloxy functions, and X − is an oxy-anion or a halide; in which a compound of formula (2), n n nin which R 5 and R 6 , which are identical or different from one another, represent a C 1 -C 5 acyl, a benzyl group or a diol-protective group, is reacted in an alcoholic solvent with from 1 to 6 equivalents of NR 2 R 3 R 4 .

专利号:US-7220870-B2
优先权日:1995-03-14
标 题:Hydrolytic kinetic resolution of cyclic substrates
发明人：JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F
权利人:HARVARD COLLEGE
摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

专利号:WO-2010096722-A1
优先权日:2009-02-20
标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
发明人：FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.

专利号:US-9662318-B2
优先权日:2012-07-16
标题 :Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
发明人：BOULOS JOHN
权利人:BARRY UNIV INC
摘要:Compositions for treating a condition associated with activity of a muscarinic receptor (e.g., one or more of M 1 , M 2 , M 3 , M 4 , M 5 ) and for anesthetizing a subject include a bitopic muscarinic antagonist or agonist. A bitopic muscarinic antagonist named JB-D4 was discovered. Additional bitopic muscarinic antagonists discovered and described herein include BK-23, HD-42, HD153, HD-185, KH-5, JM-31 and JM-32. These bitopic ligands and their structural analogs, as well as bitopic muscarinic agonists, may be used as neuromuscular blocking agents (e.g., for use in compositions for anesthetizing a subject) and for the treatment of central nervous system disorders (e.g., Parkinson's disease, Schizophrenia, etc.), Overactive Bladder Syndrome, Chronic Obstructive Pulmonary Disease, asthma, and many other diseases associated with the activation or inhibition of M 1 -M 5 acetylcholine receptors.

专利号:US-9629833-B2
优先权日:2012-07-16
标 题:Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
发明人：BOULOS JOHN
权利人:BARRY UNIV INC
摘要:The present invention is directed to a composition comprising the following compound: n n n n n n n n n n The compound is associated with activity of a muscarinic receptor (e.g. one or more M 1 , M 2 , M 3 , M 4 and M 5 .

专利号:US-4814506-A
优先权日:1986-08-26
标题:Process for preparing 3 halogeno-2-hydroxypropyltrimethylammonium halide
发明人：KATAYAMA KAZUHIKO; HAMAGUCHI SHIGEKI; KOGAME YOSHIKAZU; OHASHI TAKEHISA; WATANABE KIYOSHI
权利人:KANEGAFUCHI CHEMICAL IND
摘要:A process for preparing 3-halogeno-2-hydroxy-propyltrimethylammonium halide or especially one having the (S)-configuration, which comprises reacting 2,3-dihydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is obtained by reacting (R)-3-halogeno-1,2-propanediol with trimethylamine, with a halogenating reagent. According to the present invention, 3-halogeno-2-hydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is a useful intermediate for the synthesis of carnitine or especially (l)-carnitine, can be obtained economically, efficiently and easily.