专利号:US-9181292-B2 优先权日:2011-01-05 标题 :Methods for preparation of glycosphingolipids and uses thereof 发明人:LIANG PI-HUI 权利人:LIANG PI-HUI 摘要:Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.
专利号:US-6177572-B1 优先权日:1997-08-20 标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use 发明人:WANG FENGJIANG 权利人:SEPRACOR INC 摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.
专利号:US-10029014-B2 优先权日:2013-09-10 标题:Synthesis of novel asymmetric bow-tie PAMAM dendrimer-based conjugates for tumor-targeting drug delivery 发明人:OJIMA IWAO; WANG TAO; TENG YU-HAN 权利人:UNIV NEW YORK STATE RES FOUND 摘要:The present disclosure relates to a dendrimer-based conjugate of the formula V m -D-C-D′-(T-F) n , which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.
专利号:US-4334079-A 优先权日:1980-11-03 标 题:Synthesis of substituted benzyl esters 发明人:GREENE JAMES M; BUNNELL CHARLES A 权利人:LILLY CO ELI 摘要:A process for preparing certain substituted benzyl esters of phenylacetic acids by esterification in a solvent in which the salt of the acid is insoluble, and in the presence of a phase transfer catalyst.
专利号:US-5266702-A 优先权日:1990-09-19 标 题:1,3-oxazoline compounds useful as anionic initiators suitable for polymerization of vinyl polymers 发明人:BHASKARAN DURAIRAJ; DHAL PRADEEP K; KASHIKAR SANJAY P; KHISTI RATNAPRABHA S; SHINDE BABANRAO M; SIVARAM SWAMINATHAN 权利人:COUNCIL SCIENT IND RES 摘要:Disclosed are reactive anionic initiators of the general formula [ArCHR 1 R 2 N(R 3 R 4 R 5 R 6 ] wherein Ar=phenyl, substituted phenyl, or a heterocyclic compound, R 1 =R 2 =H, ester, cyano, alkyl, aryl, 1,3-oxazoline, N,N-dimethyl amide and other similar alpha activating groups, or combination of them, or one of R 1 or R 2 together with Ar, where Ar is a phenyl or substituted phenyl, is a nitrogen atom containing heterocyclic compound and the other being a nitrile group, R 3 , R 4 , R 5 and R 6 may be same or different and represent substituted alkyl, cycloalkyl, arylalkyl or aryl or to of the R 3 , R 4 , R 5 and R 6 together with nitrogen atom form a heterocycle with the condition that the sum of all carbon atoms of all R 3 , R 4 , R 5 and R 6 is from 12 to 50 and no more than one of the R 3 , R 4 , R 5 and R 6 is an aryl derivative. The initiators which are in the form of solids or liquids are insoluble and can be incorporated which enable the synthesis of a wide range of polymers with functional groups. These initiators are useful for polymerizing very reactive vinyl monomers such as nitrile bearing vinyl compounds.
专利号:US-3553260-A 优先权日:1967-05-29 标 题 :Radiopaque derivatives of alpha-phenoxy-phenylacetic acid 发明人:FELDER ERNST; PITRE DAVIDE 权利人:BRACCO IND CHIMICA SPA 摘要:A - (3 - N-ALKYL-N-ACETYLAMINO-2,4,6-TRIIODOPHENOXY)PHENYLACETIC ACID AND CLOSELY RELATED DERIVATIVES OF THE FORMULA 1,3,5-TRI(I-),2-((R3-PHENYL)-CH(-COOH)-O-),4-(R2-CO- N(-R1)-)BENZENE WHEREIN R1 IS LOWER ALKYL, R2 IS HYDROGEN OR LOWER ALKYL, AND R3 IS HYDROGEN, HALOGEN OR LOWER ALKYL, AND THE PHYSIOLOGICALLY TOLERATED, WATER SOLUBLE METAL OR AMINE SALTS THEREOF ARE RADIOPAQUE, TEND TO ACCUMULATE IN THE GALL BLADDER WHEN APPLIIED ORALLY, AND ARE NON-TOXIC IN EFFECTIVE AMOUNTS. THE CORRESPONDING LOWER ALKYL ESTERS ARE INTERMEDIATES IN THE SYNTHESIS OF THE ACIDS AND SALTS.
[参考文献]: Ai-Hui Tang, Et Al. Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling And Affects Hyperexcitability In A Mouse Model Of Fragile X Syndrome. J Neurosci. 2015 Mar 4;35(9):3938-45. [参考文献]: Samuel W Cramer, Et Al. Abnormal Excitability And Episodic Low-Frequency Oscillations In The Cerebral Cortex Of The Tottering Mouse. J Neurosci. 2015 Apr 8;35(14):5664-79.
合成参考文献
摘要:Zhang, M.; Su, W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 96. 摘要:Schiltz, P.; Gosmini, C., Science of Synthesis: Special Topics, (2021) 1, 92. 摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 204. 摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 239. 摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 209.