CAS: 7681-76-7; (1-Methyl-5-Nitro-1H-Imidazol-2-yl)Methyl Carbamate

上下游产品

CAS号936-05-0 1-甲基-5-硝基-2-羟甲基咪唑

1-甲基-5-硝基-2-羟甲基咪唑置于ammonium Hydroxide,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.0H,反应生成 洛硝哒唑
参考文献:Discovery Of A Dual Tubulin Polymerization And Cell Division Cycle 20 Homologue Inhibitor Via Structural Modification On Apcin
标题:Discovery Of A Dual Tubulin Polymerization And Cell Division Cycle 20 Homologue Inhibitor Via Structural Modification On Apcin
摘要:Apcin Is One Of The Few Compounds That Have Been Previously Reported As A Cdc20 Specific Inhibitor,Although Cdc20 Is A Very Promising Drug Target. We Reported Here The Design,Synthesis,And Biological Evaluations Of 2,2,2-Trichloro-1-Aryl Carbamate Derivatives As Cdc20 Inhibitors. Among These Derivatives,Compound 9F Was Much More Efficient Than The Positive Compound Apcin In Inhibiting Cancer Cell Growth,But It Had Approximately The Same Binding Affinity With Apcin In Spr Assays. It Is Possible That Another Mechanism Of Action Might Exist. Further Evidence Demonstrated That Compound 9F Also Inhibited Tubulin Polymerization,Disorganized The Microtubule Network,And Blocked The Cell Cycle At The M Phase With Changes In The Expression Of Cyclins. Thus,It Induced Apoptosis Through The Activation Of Caspase-3 And Parp. In Addition,Compound 9F Inhibited Cell Migration And Invasion In A Concentration-Dependent Manner. These Results Provide Guidance For Developing The Current Series As Potential New Anticancer Therapeutics.
DOI:10.1021/acs.Jmedchem.9B02097

专利信息

专利号:WO-2025086625-A1
优先权日:2023-10-26
标题 :Synthesis method for deuterated tinidazole
发明人：MEI SHU; GUO HUI; CHEN WULIAN
权利人:ANPEL LABORATORY TECH SHANGHAI INC
摘要:The present invention relates to a synthesis method for a deuterated tinidazole. The deuterated tinidazole is as represented by formula I, wherein one or more of R 1 -R 5 are deuterium, and the rest is hydrogen. The synthesis method comprises the step of oxidizing an intermediate B with m-chloroperoxybenzoic acid to prepare the deuterated tinidazole, wherein the oxidation is carried out under low-temperature and alkaline conditions; and the intermediate B is as represented by formula II. By using the synthesis method of the present invention, the problems of deuterium shedding and isotope dilution in the reaction process can be avoided, and the stable isotope-labeled deuterated tinidazole with the isotope abundance of > 98% is obtained with a higher yield. The prepared deuterated tinidazole can be used as an isotope internal standard reagent for the quantitative detection of tinidazole, which, for example, can be used to detect residual tinidazole in meat products by means of an isotope internal standard method, and has the advantages of having high recovery efficiency from a matrix, and being environmentally friendly and safe.

专利号:CN-117801027-A
优先权日:2023-07-03
标 题 :Synthesis of cobalt compound with spiral structure and application of cobalt compound in electrochemical detection

专利号:CN-107722288-B
优先权日:2017-10-18
标 题:Synthesis of a case of Eu-MOFs and its application in antibiotic identification

专利号:CN-108693152-B
优先权日:2018-03-06
标 题:Synthesis of tetranuclear copper-iodine cluster and antibiotic sensing application thereof

专利号:CN-107722288-A
优先权日:2017-10-18
标题 :Synthesis of a Eu‑MOFs material and its application in antibiotic identification

专利号:CN-108693152-A
优先权日:2018-03-06
标题 :Synthesis of a tetranuclear copper-iodide cluster and its application in antibiotic sensing