专利号:WO-2023111422-A1 优先权日:2021-12-17 标题:Electrolytic system for the synthesis of sodium perchlorate 发明人:RUMEAU NICOLAS; JEAN ALAIN; ONGARO CHRISTOPHE; GUERBERT ARNAUD; DELMAS ELSA 权利人:ARIANEGROUP SAS 摘要:The invention relates to an electrolytic system (1) for the synthesis of sodium perchlorate by electrochemical oxidation of sodium chlorate, said system comprising at least: - an electrolytic cell (3) defining a synthesis volume (V) and comprising an anode (5), which has an outer surface made of boron-doped diamond, a cathode (7), which has an outer surface made of stainless steel or graphite, and also a seal (9), which is between the anode and the cathode and defines the synthesis volume, the electrolytic cell having an inlet port (71), which is made through the cathode or the anode and is in communication with the synthesis volume, and an outlet port (73), which is made through the cathode or the anode and is in communication with the synthesis volume; - an assembly for the storage and circulation of an electrolyte, comprising: • a storage tank (10) which contains an electrolyte (12) comprising sodium chlorate and is in communication with the inlet port via an inlet pipe (14) intended for the introduction of the electrolyte into the synthesis volume, and • an outlet pipe (40) which is in communication with the outlet port intended for discharging the electrolyte from the synthesis volume; and - an electric generator connected to the anode and to the cathode.
专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-7230101-B1 优先权日:2002-08-28 标 题:Synthesis of methotrexate-containing heterodimeric molecules 发明人:MURTHI KRISHNA K; SMITH CHASE C 权利人:GPC BIOTECH INC 摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:
专利号:US-7247287-B2 优先权日:2003-06-11 标 题 :Synthesis of aluminophosphates and silicoaluminophosphates 发明人:CAO GUANG; SHAH MATU J 权利人:EXXONMOBIL CHEM PATENTS INC 摘要:The invention is directed to a method of synthesising silicoaluminophosphate and aluminophosphate molecular sieves using synthesis templates that contain at least one template of general formula R 1 R 2 N—R 3 , wherein R 1 and R 2 are independently selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms and hydroxyalkyl groups having from 1 to 3 carbon atoms; R 3 is selected from the group consisting of 4- to 8-membered cycloalkyl groups, optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms, and 4- to 8-membered heterocyclic groups having from 1 to 3 heteroatoms, said heterocyclic groups being optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms and the heteroatoms in said heterocyclic groups being selected from the group consisting of O, N, and S. In particular, the present invention relates to the synthesis of silicoaluminophosphate molecular sieves of the CHA framework type having a low silicon to aluminium atomic ratio.
专利号:US-6166271-A 优先权日:1996-05-10 标 题:Method for synthesis of hydrocarbon compounds containing fluorine on at least one alkyl chain carbon 发明人:SAINT-JALMES LAURENT 权利人:RHODIA CHIMIE SA 摘要:PCT No. PCT/FR97/00803 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed May 6, 1997 PCT Pub. No. WO97/43231 PCT Pub. Date Nov. 20, 1997The invention features a useful method for the synthesis of fluorinated derivatives. It is characterized in that it comprises at least one step in which a substrate comprising one sp3 hybridizing halogenophore carbon bearing at least two halogens, at least one of which is a halogen of an atomic number higher than that of fluorine, which halogenophore carbon is coupled to at least one weak hybridization atom bearing an unsaturation, is subjected to the action of one reagent comprising at least one defined compound selected among those constituted by the association of one Bronstedt base with a defined number n of hydrofluoric acid, n being at least 3 and at most 20, advantageously 15, preferably 10. This invention is useful in organic synthesis.
专利号:US-7294486-B2 优先权日:2001-09-05 标 题:Enzymatic process for the synthesis of organo-fluorine compounds 发明人:O'HAGAN DAVID; SCHAFFRATH CHRISTOPH 权利人:UNIV ST ANDREWS 摘要:There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be used to produce an 18 F labelled fluoronucleoside compound. There is also described an enzyme derived from Streptomyces cattelya which has the capacity to catalyse the synthesis of a fluoronucleoside compound.
摘要:Sano, H.; Nishimura, J., Science of Synthesis, (2010) 45, 496. 摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 572. 摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 591. 摘要:Koo, S., Science of Synthesis, (2010) 45, 1382. 摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 550.