CAS: 874-87-3; 4-(Methylthio)Benzylchloride

上下游产品

CAS号3446-90-0 4-甲硫基苄醇 | CAS号109-87-5 甲缩醛 | CAS号100-68-5 茴香硫醚 | CAS号107-06-2 1,2-二氯乙烷 | CAS号75-09-2 二氯甲烷 | CAS号107-30-2 氯甲基甲醚 | CAS号13205-48-6 4-甲硫基苯甲酸 | CAS号3795-79-7 4-(甲基硫代)苯甲酸甲酯 | CAS号40517-43-9 1-(氯甲基)-4-(甲基磺酰基)苯 | CAS号38746-92-8 2-(4-(甲硫基)苯基)乙腈 | CAS号3446-89-7 甲硫基苯甲醛 | CAS号100-44-7 氯化苄 | CAS号109418-67-9 (4-(methylthio)... | CAS号3576-65-6 2,2-dichloro-N-... | CAS号120654-20-8 N,N-dimethyl-4-... | CAS号481679-70-3 1-(dimethoxypho... | CAS号58472-47-2 1-(chloromethyl... | CAS号53605-96-2 1-(diethoxyphos...

4-(甲基硫代)苯甲酸甲酯置于吡啶,Lithium Aluminium Tetrahydride,氯化亚砜体系中,化学反应生成 4-(甲基硫代)苄氯
参考文献:363.细胞毒性化合物.第四部分:取代的苄基卤化物
标题:363.细胞毒性化合物.第四部分:取代的苄基卤化物
摘要:
DOI:10.1039/jr9630001947

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-11161823-B2
优先权日:2019-03-11
标 题 :Anticancer 1,3-dioxane-4,6-dione derivatives and method of combinatorial synthesis thereof
发明人：ISLAM IMADUL; AL-KAYSI RABIH O; BOUDJELAL MOHAMED; ALI RIZWAN; NEHDI ATEF; ALGHANEM BANDAR
权利人:NAT GUARD HEALTH AFFAIRS; KING SAUD BIN ABDULAZIZ UNIV FOR HEALTH SCIENCES; KING ABDULLAH INTERNATIONAL MEDICAL RES CENTER; KING ABDULLAH INETRNATIONAL MEDICAL RES CENTER
摘要:Compounds, methods of synthesis, and methods of cancer treatment by arylidene-1,3-dioxane-4,6-diones. A Meldrum's acid-based chemistry and hybrid solid-liquid method. The method includes protection of ketone and aldehyde components and simultaneous immobilization on the solid phase, introduction of substituents, grafts and derivatives compatible with the protection, detachment and restoration of active carbonyl reactivity, reaction of ketone library with malonate, reacting of the products with the aldehyde library in liquid phase and separation of the products by preparative HPLC.

专利号:US-3563958-A
优先权日:1968-04-02
标 题:Esterification of arylmethylene sulfonium resins with n - protected amino acids for use in solid-phase peptide synthesis
发明人：DORMAN LINNEAUS C
权利人:DOW CHEMICAL CO
摘要:THE MERRIFIELD SOLID-PHASE PEPTIDE SYNTHESIS IS IMPROVED BY BONDING THE AMINO ACID TO THE SUPPORTING RESIN THROUGH REACTION OF AN N-PROTECTED AMINO ACID (I) WITH AN ARYLMETHYLENE SULFONIUM RSIN (II) TO FORM AN AMINO ACID RESIN BENZYL ESTER (IV): P-NH-CH(-R)-COOH + X-AR-CH2-S(+)(-R1)-R2.Y(-) --> P-NH-CH(-R)-COO-CH2-AR-X ADVANTAGES OF THIS PROCESS INCLUDE BROADER SCOPE, MILD CONDITIONS, HIGHER RESIN ESTER CAPACITIES AND IMPROVED YIELDS. HIGHEST YIELDS ARE OBTAINED WHEN A BASIC SALT OF THE SULFONIUM RESIN IS USED.