CAS: 109887-53-8; Rel-(3R,4S)-4-(4-Fluorophenyl)-1-Methyl-3-Piperidinemethanol

相似化合物

105812-81-5 100332-20-5 389573-45-9

专利信息

专利号:US-6777554-B2
优先权日:2001-02-05
标题 :Preparation of N-methylparoxetine and related intermediate compounds
发明人：FINKELSTEIN NINA
权利人:TEVA PHARMA
摘要:The present invention provides a process for preparing N-methylparoxetine, an intermediate in the synthesis of paroxetine, by reacting sesamol-tetrabutylammonium salt with CIPMA. The present invention is not limited to the synthesis of N-methylparoxetine, but also includes other similar compounds.

专利号:US-6066737-A
优先权日:1995-12-28
标题:Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine
发明人：ADGER BRIAN MICHAEL; POTTER GERARD ANDREW; FOX MARTIN EDWARD
权利人:CHIROTECH TECHNOLOGY LTD
摘要:The subject invention pertains to optically-enriched compounds of formula (1), wherein Ar is a C 6-20 aryl group; and R 1 and R 2 are independently H, alkyl or aryl. The subject invention also pertains to method of preparing these compounds. The subject compounds can be prepared by reduction of the corresponding 1,4-dihydropyridine-3-aldehyde, e.g., using hydrogen an a catalyst. The aldehyde can be prepared by hydrolytic cleavage of an aminal obtainable by the reaction of 3-pyridinecarboxaldehyde and a chiral C-2 symmetric diamine, an then stereoselective introduction of the Ar and COOCHR 1 R 2 groups. ##STR1##

专利号:WO-9724323-A1
优先权日:1995-12-28
标题:Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine

专利号:EP-0874820-A1
优先权日:1995-12-28
标题:Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine