CAS: 149965-40-2; (5-Bromo-2-Chlorophenyl)Methanol

相似化合物

21739-92-4 76008-73-6 189628-37-3

上下游产品

CAS号21739-92-4 5-溴-2-氯苯甲酸 | CAS号42860-02-6 3-溴-5-氯苯甲酸 | CAS号251085-87-7 2-氯-5-溴苯甲酸甲酯 | CAS号76008-73-6 2-氯-5-溴苯甲酸乙酯 | CAS号21900-52-7 5-溴-2-氯苯甲酰氯 | CAS号149965-41-3 5-溴-2-氯苄基溴 | CAS号189628-37-3 5-溴-2-氯苯甲醛

2-氯苯甲醛置于sodium Tetrahydroborate,N-溴代丁二酰亚胺(Nbs)体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应 14.5H,反应生成5-溴-2-氯苯甲醇
参考文献:一种达格列净的制备方法
标题:一种达格列净的制备方法
摘要:本发明涉及一种达格列净的制备方法,以2‑氯苯甲醛为起始原料,经溴代,还原,氯代合成5‑溴‑2‑氯苄氯,与苯乙醚经付‑克烷基化反应合成5‑溴‑2‑氯‑4'‑乙氧基二苯甲烷,然后与2,3,4,6‑四‑o‑三甲基硅基‑d‑葡萄糖酸内酯经缩合,脱三甲基硅基保护,醚化,还原脱甲氧基得到降糖药达格列净.本发明的优点在于:本发明达格列净的制备方法,以2‑氯苯甲醛为起始原料,与5‑溴‑2‑氯苯甲酸相比,价格便宜易得,工艺容易实现工业化,且合成过程中,不会用到产生剧毒的物质原料,进而无危险工艺,且该合成路线短,新颖,使得操作简便,通过本发明的合成路线,能够提高最终产品的纯度,可使纯度达到99%以上.

专利信息

专利号:US-9018249-B2
优先权日:2011-09-13
标题 :SGLT inhibitors
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).

专利号:US-2014228303-A1
优先权日:2011-06-13
标题 :Novel sglt inhibitors
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).

专利号:CN-1946710-A
优先权日:2004-05-03
标 题 :Diastereoselective Synthesis of 6-Bromo-4-(3-Chlorophenyl)-2-Methoxyquinoline

专利号:US-9738661-B2
优先权日:2006-10-27
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; SUMMA VINCENZO; HARPER STEVEN; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.