CAS: 16239-18-2; 1,6-Dibromonaphthalen-2-Ol

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573-97-7 30478-88-7 132178-78-0

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CAS号15231-91-1 6-溴-2-萘酚 | CAS号135-19-3 2-萘酚 | CAS号573-97-7 1-溴-2-萘酚 | CAS号17096-15-0 1,1'-硫联二(2-萘酚) | CAS号861799-05-5 6,6'-dibromo-1,... | CAS号60930-64-5 bis-(2-acetoxy-... | CAS号66996-59-6 1,6-二溴-2-甲氧基萘 | CAS号10035-10-6 氢溴酸 | CAS号64-19-7 冰醋酸 | CAS号42924-53-8 萘丁美酮 | CAS号5111-65-9 2-溴-6-甲氧基萘 | CAS号57-27-2 吗啡 | CAS号602-09-5 1,1'-联-2-萘酚 | CAS号135-19-3 2-萘酚 | CAS号6968-28-1 4-溴邻苯二甲酸 | CAS号76-57-3 可待因 | CAS号15231-91-1 6-溴-2-萘酚

2-萘酚置于aluminum Tri-Bromide,碘苯二乙酸体系中,用 乙腈 用作溶剂,化学反应生成1,6-二溴-2-萘酚
参考文献:通过新型 I(III) 试剂对苯酚进行实用,温和且高效的亲电溴化:Pida-albr3 系统†
标题:通过新型 I(III) 试剂对苯酚进行实用,温和且高效的亲电溴化:Pida-albr3 系统†
摘要:在高效且非常温和的反应条件下开发了一种实用的苯酚和苯酚醚亲电溴化方法.研究了广泛的芳烃,包括苯并咪唑和咔唑核心以及萘普生和扑热息痛等止痛药.新型 I( Iii ) 基溴化试剂phioacbr通过混合 Pida 和 Albr 3易于制备.我们的 Dft 计算表明,这可能是溴化活性物质,它是原位制备的或离心后分离的.制备后 1 个月内证实其在 4oc 下的稳定性,未观测到其反应性显着损失.此外,2-萘酚的克级溴化反应具有优异的收率.即使对于空间位阻底物,也观测到适度非常好的反应性.
Doi:10.1039/c8Ra02982B

专利信息

专利号:US-4628123-A
优先权日:1984-10-23
标题:Process for the synthesis of 2-methoxy-6-bromo-naphthalene
发明人：BORSOTTI GIAMPIERO
权利人:MONTEDISON SPA
摘要:A process for the synthesis of 2-methoxy-6-bromo-naphthalene, wherein the 2-methoxy-naphthalene is brominated by means of Br 2 to 1,6-dibromo-2-methoxy-naphthalene and the latter is then dehalogenated, without any separation from the liquid medium of reaction, by addition of iron.

专利号:US-9764047-B2
优先权日:2009-04-17
标题:Method for obtaining novel derivatives of naphthalene for the in vivo diagnosis of alzheimer's disease
发明人：SABLÓN CARRAZANA MARQUIZA; RODRIGUEZ-TANTY CHRYSLAINE; PERERA PINTADO ALEJANDRO; RIVERA MARRERO SUCHITIL; PEREZ PERERA RAFAELA; LÓPEZ BARROSO ROSA MARIA; PRATS CAPOTE ANAIS; VÉLEZ CASTRO HERMÃ?N; PÉREZ MARTÃ?NEZ CARLOS SERAFIN; VALDÉS SOSA PEDRO
权利人:SABLÓN CARRAZANA MARQUIZA; RODRIGUEZ-TANTY CHRYSLAINE; PERERA PINTADO ALEJANDRO; RIVERA MARRERO SUCHITIL; PEREZ PERERA RAFAELA; LÓPEZ BARROSO ROSA MARIA; PRATS CAPOTE ANAIS; VÉLEZ CASTRO HERMÃ?N; PÉREZ MARTÃ?NEZ CARLOS SERAFIN; VALDÉS SOSA PEDRO; CENTRO DE NEUROCIENCIAS DE CUBA
摘要:This invention relates to a chemistry branch, particularly to the field of compounds' organic synthesis that belongs to the aromatic bicyclic or naphthalene category, used in the detection of amyloid sheets. These new naphthalene derivatives have a general formula: Wherein R represents mutually independent groups. In I: R 1 :-alkylenyl-C(O)NH-alkylenyl-R 3 , -alkylenyl-C(O)O—R 4 , R 3 :—COOH, —OH, —SH, —NH 2 , -alkyl-NH-alkyl-N-dithiocarbamate alkaline earth metal salts, R 4 : H, succinimidyl group, R 2 : —H,-alkyl. In II: R 1 : -alkyl, -alkylenyl-halide-alkylenyl-hydroxyl-alkylenyl-O-aryl, —O-alkylsulfonate alkylenyl, R 2 : -halide-alkylenyl-O-aryl, -alkylenyl-O-alkylsulfonate, -alkylenyl-halide-, —CH(O), —HCâ•?C(CN) 2 , —HCâ•?CHNO 2 , -alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl-N-dithiocarbamate alkaline salts. The terms “alkylâ€? and “alkylenylâ€? refer to linear or branched aliphatic chains, preferably from 1 to 4 carbon atoms and the term halide to fluorine, bromine or iodine. These compounds are neutral, lipophilic and have low molecular weight and therefore they cross the blood brain barrier and attach to the amyloid sheets. The present invention provides procedures for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger-scale manufacturing. We are unaware whether th compounds presented in this invention have been previously reported.

专利号:EP-0179447-A1
优先权日:1984-10-23
标 题 :Process for the synthesis of 2-methoxy-6-bromo-naphthalene