CAS: 27298-97-1; (S)-1-(4-Bromophenyl)Ethanamine

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CAS号24358-62-1 4-溴-alpha-苯乙胺 | CAS号99-90-1 4-溴苯乙酮 | CAS号182141-70-4 N-[(1S)-1-(4-溴苯... | CAS号105-53-3 丙二酸二乙酯 | CAS号2354-91-8 2,2,2-Trifluoro... | CAS号36244-70-9 (S)-1-(4-氰基苯基)乙胺 | CAS号847728-89-6 (s)-[1-(4-溴-苯基)...

4-溴-α-甲基苄胺置于sodium Pyruvate,Recombinant N-Terminal His-Tag Shinorizobium Sp. Rac02 (R)-Selective Transaminase体系中,用 二甲基亚砜 用作溶剂,化学反应 8.0H,以99%的收率获得
参考文献:如何识别和表征新型转氨酶两种具有相反对映选择性的新型转氨酶用于合成光学活性胺
标题:如何识别和表征新型转氨酶两种具有相反对映选择性的新型转氨酶用于合成光学活性胺
摘要:胺转氨酶 (Tas) 是一种有吸引力的生物催化剂,可用于合成代表高价值 Api 基序的手性芳香胺.工业上对生产 Api 手性胺的新方法的需求增加,导致新 Ta 的出现.加入当前的 Ta 相关研究浪潮,本研究报告了编码来自pseudomonas Psychrotolerans Ta ( Pps-Ta ) 的 ( S )-选择性 Ta 和来自shinorizobium Sp.的 ( R )-选择性 Ta 的基因的鉴定.助听器_-Ta) 通过序列数据挖掘.新型 Ta 的功能分析揭示了它们的 Ph 曲线,热稳定性,最佳缓冲系统,Dmso 耐受性和外消旋 1-苯基乙烷-1-胺的动力学拆分 (Kr) 的操作稳定性.( S )-选择性pps-Ta 即使在高温和高 Ph 值下也能保持其操作稳定性,使外消旋体的转化率接近高选择性 Kr 的最佳约 50% 值.尽管活性较低,但 ( R )-选择性srr
Doi:10.1016/j.Mcat.2022.112660

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:US-5300437-A
优先权日:1989-06-22
标 题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; MATCHAM GEORGE W; ZEITLIN ANDREW L
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.

专利号:US-5169780-A
优先权日:1989-06-22
标题:Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; ZEITLIN ANDREW L; MATCHAM GEORGE W; ROZZELL JR JAMES D
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.

专利号:US-8487094-B2
优先权日:2008-07-25
标题 :Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
发明人：FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA
权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT
摘要:Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).