专利号:WO-9507882-A1 优先权日:1993-09-14 标 题:Synthesis of amido acids from carboxylic acid esters and amino acid salts 发明人:HEINZMAN STEPHEN WAYNE; DUPONT JEFFREY SCOTT 权利人:PROCTER & GAMBLE 摘要:Chemical synthesis of amido acids, and their conversion to amido acid phenyl ester sulfonates for use as bleach activators, starting from carboxylic acid esters and amino acid salts.
专利号:US-5681971-A 优先权日:1994-12-12 标题 :Synthesis of fatty N-alkyl amides 发明人:SCHEIBEL JEFFREY JOHN; SHUMATE ROBERT EDWARD 权利人:PROCTER & GAMBLE 摘要:Fatty N-alkyl amides are synthesized directly from glycerides (preferably triglycerides) and amines in the absence of a catalyst, and preferably without a solvent. The method provides for products suitable for use without further purification, preferably after separating the glycerol and amide products. The disclosed method is also useful for the synthesis of glycerol from glycerides and ammonia and/or primary amines.
专利号:US-7339065-B2 优先权日:2003-07-21 标题 :Design and synthesis of optimized ligands for PPAR 发明人:AVERY MITCHELL A; PERSHADSINGH HARRIHAR A 权利人:BETHESDA PHARMACEUTICALS INC; UNIV MISSISSIPPI 摘要:This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.
专利号:US-5188769-A 优先权日:1992-03-26 标 题:Process for reducing the levels of fatty acid contaminants in polyhydroxy fatty acid amide surfactants 发明人:CONNOR DANIEL S; SCHEIBEL JEFFREY J; MURCH BRUCE P; MAO MARK H; GOSSELINK EUGENE P; SEVERSON JR ROLAND G 权利人:PROCTER & GAMBLE 摘要:The synthesis of polyhydroxy fatty acid amide surfactants exemplified by the compound C11H23C(O)N(CH3)CH2[CHOH]4CH2OH by reacting a fatty acid ester with an N-alkyl sugar amine can result in contamination of the product surfactant by residual sources of fatty acids. These residual fatty acids may be unacceptable in high sudsing detergent compositions, such as dishwashing liquids, especially with Ca or Mg cations. The process of this invention reacts such contaminants with alkyl amines or, especially, ethanolamine, to convert them into fatty alkyl- or alkanolamides, which are quite acceptable in fully-formulated detergent compositions for home or industrial use.
专利号:WO-9507881-A1 优先权日:1993-09-14 标题:Synthesis of sarcosinate surfactants 发明人:HEINZMAN STEPHEN WAYNE; DUPONT JEFFREY SCOTT 权利人:PROCTER & GAMBLE 摘要:A method for preparing sarcosinate amido acids and salts thereof of formula (IA) wherein R is a C1 or higher hydrocarbyl substituent, and M is a cationic moiety selected from alkali metal salts and hydrogen, comprising the steps of (a) reacting under anhydrous conditions, in the presence of a base catalyst with basicity equal to or greater than alkoxide catalyst, a carboxylic acid ester of formula (II) with a sarcosine amino acid salt of structure (B) wherein R is as described before, R1 is a C¿1? or higher hydrocarbyl substituent, and M is an alkali metal salt; and (b) optionally, neutralizing the sarcosinate amido acid salt formed by step (a) to form the sarcosinate amido acid, whereby M is hydrogen in formula (IA).
专利号:WO-9522519-A1 优先权日:1994-02-17 标题 :Synthesis of polyhydroxy fatty acid amides from triglycerides 发明人:SCHEIBEL JEFFREY JOHN; REILMAN RANDALL THOMAS; SHERMAN JOE FREDERICK 权利人:PROCTER & GAMBLE 摘要:Fats and oils such as hardened palm kernel oil are reacted directly with N-substituted polyhydroxy amines to provide high yields of N-substituted polyhydroxy fatty acid amide surfactants having improved odors and low fatty acid content. Hardened palm kernel oil is reacted with N-methylglucamine in the presence of an ethoxylated alcohol, but in the absence of methanol solvent, using sodium propylene glycolate catalyst to provide the mixed corresponding fatty acid amide of N-methylglucamine.