专利号:US-7700654-B2 优先权日:2005-02-05 标 题:Isolation of N-butylbenzenesulfonamide, synthesis of benzenesulfonamide derivatives, and use of N-butylbenzenesulfonamide and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma 发明人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA 权利人:LOHMANN THERAPIE SYST LTS 摘要:A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma, the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.
专利号:US-8481519-B2 优先权日:2005-02-05 标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy 发明人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA 权利人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA; LOHMANN THERAPIE SYST LTS 摘要:A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.
专利号:EP-0333557-B1 优先权日:1988-03-17 标 题:Process for the preparation of arylsulfonylalkylamides 发明人:COMMANDEUR RAYMOND; GHENASSIA ELIE 权利人:ATOCHEM ELF SA 摘要:Process for the synthesis of arylsulphonylalkylamides in which an arylsulphonyl halide is placed in contact with an excess of alkylamine and an aqueous solution of alkaline agent in excess in relation to the arylsulphonyl halide and then the water and excess amine are removed from the organic phase; the arylsulphonylalkylamide is then isolated. This process is particularly suited for N-n-butylbenzenesulphonamide which is obtained in a thermally stable quality and which can be advantageously employed as a plasticiser for polyamides.
专利号:US-2009143466-A1 优先权日:2005-02-05 标题 :Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy
专利号:US-2008177107-A1 优先权日:2005-02-05 标题 :Isolation of N-Butylbenzenesulfonamide, Synthesis of Benzenesulfonamide Derivatives, and Use of N-Butylbenzenesulfonamide and Benzenesulfonamide Derivatives for Treating Benign Prostatic Hyperplasia and/or Prostate Carcinoma
专利号:AU-2006210040-B2 优先权日:2005-02-05 标 题:Isolation of N-butylbenzenesulfonamide, synthesis of benzenesulfonamide derivatives, and use of N-butylbenzenesulfonamide and benzenesulfonamide derivatives for the treatment of benign prostate hyperplasia and/or prostate carcinoma
[参考文献]: Ganesh Kumar, Et Al. Brain Uptake, Pharmacokinetics, And Tissue Distribution In The Rat Of Neurotoxic N-Butylbenzenesulfonamide. Toxicol Sci. 2007 Jun;97(2):253-64. [参考文献]: M J Strong, Et Al. N-Butylbenzenesulphonamide, A Novel Neurotoxic Plasticising Agent. Lancet. 1990 Sep 8;336(8715):640. [参考文献]: Maria Papaioannou, Et Al. Nbbs Isolated From Pygeum Africanum Bark Exhibits Androgen Antagonistic Activity, Inhibits Ar Nuclear Translocation And Prostate Cancer Cell Growth. Invest New Drugs. 2010 Dec;28(6):729-43. [参考文献]: Niklas Janzen, Et Al. Vertical Flow Soil Filter For The Elimination Of Micro Pollutants From Storm And Waste Water. Chemosphere. 2009 Nov;77(10):1358-65. [参考文献]: P Duffield, Et Al. Analysis Of The Neurotoxic Plasticizer N-Butylbenzenesulfonamide By Gas Chromatography Combined With Accurate Mass Selected Ion Monitoring. J Anal Toxicol. 1994 Nov-Dec;18(7):361-8.
合成参考文献
摘要:Kimura, T., Science of Synthesis Knowledge Updates, (2016) 2, 414. 摘要:Folgueiras-Amador, A. A.; Hodgson, J. W.; Brown, R. C. D., Science of Synthesis: Special Topics, (2021) 1, 421. 摘要:Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*., 15(110), 1979 摘要:Gigiena i Sanitariya. For English translation, see HYSAAV., 39(4)(86), 1974 参考文献:10.1055/s-2006-946638 摘要:Schleich S, Papaioannou M, Baniahmad A, Matusch R. Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity. Planta Med. 2006 Jul;72(9):807–13. doi: 10.1055/s-2006-946638.