CAS: 3687-18-1; 3-Aminopropane-1-Sulfonic Acid

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72372-71-5 1131576-06-1 77693-74-4

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Benzyl N-(3-Mercaptopropyl)Carbamate置于甲酸,双氧水体系中,用 水 用作溶剂,化学反应 12.0H,以34 Mg的收率获得3-氨基丙烷磺酸
参考文献:由α,β-不饱和腈合成高牛磺酸和1-取代高牛磺酸
标题:由α,β-不饱和腈合成高牛磺酸和1-取代高牛磺酸
摘要:摘要 通过将硫代乙酸迈克尔加成到脂肪族和芳香族α,β-不饱和腈上,然后氢化铝锂介导的还原和甲酸氧化,可以很容易地以令人满意的非常好收率合成高牛磺酸和一系列1-取代的高牛磺酸.尝试以β,β-二取代的丙烯腈为起始原料合成1,1-二取代的高牛磺酸,但由于空间位阻而失败.当前的方法是合成1-取代的高牛磺酸的有效方法. 通过将硫代乙酸迈克尔加成到脂肪族和芳香族α,β-不饱和腈上,然后氢化铝锂介导的还原和甲酸氧化,可以很容易地以令人满意的非常好收率合成高牛磺酸和一系列1-取代的高牛磺酸.尝试以β,β-二取代的丙烯腈为起始原料合成1,1-二取代的高牛磺酸,但由于空间位阻而失败.当前的方法是合成1-取代的高牛磺酸的有效方法.
Doi:10.1055/s-0031-1289773

专利信息

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

专利号:US-5300437-A
优先权日:1989-06-22
标 题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; MATCHAM GEORGE W; ZEITLIN ANDREW L
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.

专利号:US-5169780-A
优先权日:1989-06-22
标题:Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; ZEITLIN ANDREW L; MATCHAM GEORGE W; ROZZELL JR JAMES D
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-4950606-A
优先权日:1989-06-22
标题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; ZEITLIN ANDREW L; MATCHAM GEORGE W
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.

专利号:US-6989401-B2
优先权日:2000-07-19
标题:Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
发明人：MAEDA KAZUHIRO; SONDA SHUJI; TAKEMOTO TADAHIRO; GOTO TOMOKAZU; KOBAYASHI FUJIO; KAJII MASAHIKO; KOMORITA NARUYASU; HIRAYAMA FUMIHIRO
权利人:MITSUBISHI PHARMA CORP
摘要:The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.