尿素置于硫化氢体系中,化学反应生成 硫氰酸胍 参考文献:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: C: Mvol.D1,45.8.4.5.1,Page 421-422 标题:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: C: Mvol.D1,45.8.4.5.1,Page 421-422
专利信息
专利号:US-11466283-B2 优先权日:2016-08-18 标 题:Plants and methods for increasing and decreasing synthesis of cannabinoids 发明人:ROSCOW ROBERT F 权利人:CANOPY GROWTH CORP 摘要:This disclosure relates to new plants and methods for increasing and decreasing synthesis of cannabinoids. The plants disclosed herein comprise unnatural ratios and concentrations of cannabinoids in plants of genus Cannabis . The methods disclosed herein comprise manipulating the biosynthetic pathway of cannabinoids to produce plants of genus Cannabis with unnatural ratios and concentrations of cannabinoids.
专利号:US-6642367-B2 优先权日:1995-03-06 标 题:Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom 发明人:COOK PHILLIP DAN; SANGHVI YOGESH S; SPRANKLE KELLY G; ROSS BRUCE S; GRIFFEY RICH H; SPRINGER ROBERT H 权利人:ISIS PHARMACEUTICALS INC 摘要:Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
专利号:US-6133242-A 优先权日:1993-10-15 标题 :Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes 发明人:ZALEWSKI ANDREW; SHI YI 权利人:THOMAS JEFFERSON UNIVERISITY 摘要:A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise antisense oligonucleotides specific for nuclear proto-oncogenes. Preferably, antisense compounds of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.
专利号:US-6217857-B1 优先权日:1989-06-28 标题 :Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof 发明人:MOSMANN TIMOTHY R; MOORE KEVIN W; BOND MARTHA W; VIEIRA PAULO J M 权利人:SCHERING CORP 摘要:Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIF's, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-gamma.
专利号:US-5231012-A 优先权日:1989-06-28 标 题:Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) 发明人:MOSMANN TIMOTHY R; MOORE KEVIN W; BOND MARTHA W; VIEIRA PAULO J M 权利人:SCHERING CORP 摘要:Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs) (now known as interleukin -10), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon- gamma .
专利号:EP-0567450-B1 优先权日:1989-06-28 标题 :Cytokine synthesis inhibitory factor and methods of using same 发明人:MOSMANN TIMOTHY R; MOORE KEVIN W; BOND MARTHA W; VIEIRA PAULO J M 权利人:SCHERING CORP 摘要:Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon- gamma .
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合成参考文献
参考文献:10.2144/96212bm15 摘要:Vareli K, Frangou-Lazaridis M. Modification of the acid guanidinium thiocyanate-phenol-chloroform method for nuclear RNA isolation. Biotechniques. 1996 Aug;21(2):236–7. doi: 10.2144/96212bm15. 摘要:Singh S, Malhotra V, Sarin SK. Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in India. Indian J Med Res. 2004 Apr;119(4):145–8. 参考文献:10.1021/jp311425v 摘要:Hunger J, Neueder R, Buchner R, Apelblat A. A conductance study of guanidinium chloride, thiocyanate, sulfate, and carbonate in dilute aqueous solutions: ion-association and carbonate hydrolysis effects. J Phys Chem B. 2013 Jan 17;117(2):615–22. doi: 10.1021/jp311425v. 参考文献:10.1016/j.jviromet.2003.10.003 摘要:Whittier CA, Horne W, Slenning B, Loomis M, Stoskopf MK. Comparison of storage methods for reverse-transcriptase PCR amplification of rotavirus RNA from gorilla (Gorilla g. gorilla) fecal samples. J Virol Methods. 2004 Mar 01;116(1):11–7. doi: 10.1016/j.jviromet.2003.10.003. 参考文献:10.1038/367390a0 摘要:Gillespie DH, Cuddy KK, Kolbe T, Marks DI. Dissolve and capture: a strategy for analysing mRNA in blood. Nature. 1994 Jan 27;367(6461):390–1. doi: 10.1038/367390a0.