CAS: 877-66-7; (4-(Methylsulfonyl)Phenyl)Hydrazine

上下游产品

CAS号98-57-7 4-氯苯基甲基砜 | CAS号3466-32-8 4-溴苯甲砜 | CAS号832714-08-6 4-chloro-1-(4-m...

对氟苯甲砜置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应生成 4-甲磺酰基苯肼盐酸盐
参考文献:谷氨酸衍生物作为抗氧化剂和消炎药的设计,合成及生物学评价
标题:谷氨酸衍生物作为抗氧化剂和消炎药的设计,合成及生物学评价
摘要:合成了一系列谷氨酸衍生物,并评估了其抗氧化活性和稳定性.我们发现了几种有效且稳定的谷氨酸衍生物.其中,化合物12B显示出非常好的体外活性,化学稳定性和细胞毒性.原型化合物12B在lps刺激的raw 264.7细胞系和斑马鱼模型中显示出抗炎作用.
DOI:10.1016/j.Bmcl.2017.11.012

专利信息

专利号:US-7442802-B2
优先权日:2002-06-27
标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：BANDARAGE UPUL K; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-9856218-B2
优先权日:2013-03-15
标题:Inhibitors of PRMT5 and methods of their use
发明人：BAIOCCHI ROBERT A; LI CHENGLONG; LAI HONGSHAN; SIF SAID
权利人:OHIO STATE INNOVATION FOUNDATION
摘要:In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.