专利号:US-8779201-B2 优先权日:2007-10-02 标题 :Process for preparing benzofurans 发明人:EKLUND LARS 权利人:CAMBREX KARLSKOGA AB 摘要:There is provided a process for the preparation of a compound of formula (I), wherein R 1 , R 2 , R 3 , R 4 , X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.
专利号:US-2023219994-A1 优先权日:2019-08-14 标 题:Modified nucleoside and synthesis method therefor 发明人:CAI YUNSONG; LI HANGWEN; LIU LIANXIAO; LI NING 权利人:STEMIRNA THERAPEUTICS CO LTD 摘要:A modified cytidine compound, that is, an aminooxy group is modified at the 4-position of a cytidine pyrimidine ring to produce derivative cytidine and nucleic acid containing the derivative cytidine, such as RNA. The expression level of the nucleic acid containing the modified cytidine, in particular mRNA, in the body is significantly improved.
专利号:CN-112745244-B 优先权日:2019-10-30 标 题 :A kind of intermediate of siponimod and its synthesis method
专利号:US-9663511-B2 优先权日:2012-03-26 标题:Sphingosine 1-phosphate receptor antagonists 发明人:SWENSON ROLF E 权利人:ARROYO BIOSCIENCES LLC 摘要:The present invention relates to sphingosine-1-phosphate (S1P) receptors and compounds of the general formula: n nthat are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1-phosphate receptor 2 (S1P 2 ) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1P 2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1P 2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.
专利号:CN-112745244-A 优先权日:2019-10-30 标题 :A kind of intermediate of simpomod and its synthesis method