CAS: 106-93-4; 1,2-Dibromoethane

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CAS号54509-73-8 ethene | CAS号105089-47-2 N-bromo-1,8-nap... | CAS号71-43-2 苯 | CAS号74-86-2 乙炔 | CAS号107-21-1 乙二醇 | CAS号107-06-2 1,2-二氯乙烷 | CAS号593-60-2 溴乙烯 | CAS号67-56-1 甲醇 | CAS号540-63-6 1,2-乙二硫醇 | CAS号74-96-4 溴乙烷 | CAS号1112193-37-9 2,3-二氢-1H-吡啶并[2... | CAS号106-58-1 1,4-二甲基哌嗪 | CAS号105-84-0 N,N',N''-三甲基二乙烯三胺 | CAS号105-78-2 1,2-Ethanediami... | CAS号110-70-3 N,N'-二甲基乙二胺 | CAS号1074-56-2 1-CHLORO-4-(VIN... | CAS号6483-50-7 1,4-二乙基哌嗪 | CAS号111-74-0 N N'-二乙基乙二胺 | CAS号105-93-1 1,4,7-三乙基二亚乙基三胺 | CAS号24426-33-3 N,N',N'',N'''-t...

乙二醇置于1,2-二溴四氯乙烷,三苯基膦体系中,用 二氯甲烷 用作溶剂,化学反应 0.15H,以96%的收率获得1,2-二溴乙烷
参考文献:1,2-二溴四氯乙烷:一种有效的试剂,可通过修饰的appel反应进行许多转化
标题:1,2-二溴四氯乙烷:一种有效的试剂,可通过修饰的appel反应进行许多转化
摘要:已开发出一种高效且简便的方法,可在温和的条件下使用三苯基膦(pph $ _ {3})$ / 1,2-二溴四氯乙烷(dbtce)络合物在多种条件下从多种醇中合成烷基溴化物,且收率极高,且时间短( 5分钟).该方法也可以用于以非常高的对映体过量将手性醇转化为其相应的溴化物.Pph $ _ {3} $ / Dbtce配合物也已成功应用于温和条件下环状醚的开环反应.通过在这项工作中对appel反应方案进行修改,还可以在非常温和的实验条件下成功完成酯化,酰胺化和酸酐的形成.
Doi:10.3906/kim-1804-41

专利信息

专利号:US-6479685-B2
优先权日:1998-01-09
标题 :Metallocene catalysts for synthesis of high-melting polyolefin copolymer elastomers
发明人：WAYMOUTH ROBERT M; KRAVCHENKO RAISA L; MACIEJEWSKI PETOFF JENNIFER; HUNG JOYCE
权利人:TRUSTEES OF THE LELAND STANDAR
摘要:Metallocene catalysts having plural coordination geometries for synthesis of high melting polyolefin copolymers suitable as thermoplastic elastomers. The inventive catalysts comprise unbridged, substituted or unsubstituted cyclopentadienyl metallocene catalysts that are capable of inter-converting between states with different polymerization or copolymerization characteristics, which interconversion is controlled by selecting the substituents of the cyclopentadienyl ligands so that the rate of interconversion of the two states is within several orders of magnitude of the rate of formation of a single polymer chain. Where r i >r f the polymer can be characterized as multiblock; where r i
专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-5220016-A
优先权日:1991-07-29
标 题:Synthesis of navelbine analogs
发明人：MAGNUS PHILIP D; THURSTON LEE S
权利人:UNIV TEXAS
摘要:The invention is a de novo synthesis of the norcatharanthine moiety of navelbine. The synthesis includes condensing a Grignard reagent prepared from an amine-protected R(+)-piperidinyl methanol with an N-protected 2-methoxyoxalyl indole. The indole N-protecting group is removed to provide a 2-methoxyindole hydroxy ester which is coupled to vindoline. After removal of the amineprotecting group from the piperidinyl group, ring closure to the indole moiety provides dihydrodesethyl navelbine. Other derivatives and analogs of navelbine with potential clinical applications in cancer chemotherapy may be readily synthesized. The synthesis opens a route to a wide variety of navelbine modifications, including modifications at or near the tryptamine bridge.

专利号:US-2019047933-A1
优先权日:2016-03-15
标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid
发明人：ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÃœCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám
权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC
摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme

专利号:US-2022267266-A1
优先权日:2019-07-09
标 题 :Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT
权利人:FERMENTA BIOTECH LTD
摘要:Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

专利号:US-2013196019-A1
优先权日:2010-03-18
标 题:Silicon-containing block co-polymers, methods for synthesis and use
发明人：WILLSON C GRANT; BATES CHRISTOPHER M; STRAHAN JEFFREY; ELLISON CHRISTOPHER JOHN; MUELLER BRENNEN
权利人:WILLSON C GRANT; BATES CHRISTOPHER M; STRAHAN JEFFREY; ELLISON CHRISTOPHER JOHN; MUELLER BRENNEN; NAT UNIVERSITY OF SINAPORE
摘要:The present invention describes the synthesis of silicon-containing monomers and copolymers. The synthesis of a monomer, trimethyl-(2-methylenebut-3-enyl)silane (TMSI) and subsequent synthesis of diblock copolymer with styrene, forming polystyrene-block-polytrimethylsilyl isoprene, and synthesis of diblock copolymer Polystyrene-block-polymethacryloxymethyltrimethylsilane or PS-b-P(MTMSMA). These silicon containing diblock copolymers have a variety of uses. One preferred application is as novel imprint template material with sub-100 nm features for lithography.