CAS: 1635-61-6; 5-Chloro-2-Nitroaniline

相似化合物

95-83-0 6641-64-1 2683-43-4

上下游产品

CAS号100-00-5 对硝基氯苯 | CAS号5443-33-4 5-氯-2-硝基乙酰苯胺 | CAS号611-06-3 2,4-二氯硝基苯 | CAS号700-37-8 4-氯-2-氟硝基苯 | CAS号96042-30-7 2-[2-[(E)-2-[4-... | CAS号67-56-1 甲醇 | CAS号124-41-4 甲醇钠 | CAS号610-40-2 3,4-二硝基氯苯 | CAS号108-42-9 间氯苯胺 | CAS号588-07-8 3'-氯乙酰苯胺 | CAS号111861-03-1 1-乙酰基-4-(3-氨基-4... | CAS号35966-84-8 5-氯-N-甲基-2-硝基苯胺 | CAS号43156-48-5 4-(苯硫基)-1,2-苯二胺 | CAS号57780-75-3 2-硝基-5-(丙基硫代)苯胺 | CAS号5443-33-4 5-氯-2-硝基乙酰苯胺 | CAS号405169-16-6 多韦替尼 | CAS号43156-47-4 2-硝基-5-苯巯基苯胺 | CAS号3584-66-5 5-氯-2-(三氯甲基)苯并咪唑 | CAS号144729-44-2 4-氯-3-硝基苯-1,2-二胺 | CAS号18333-80-7 2-[(4-nitro-2,1...

对硝基氯苯置于n-Lithiotriphenylphosphinimine体系中,用 四氢呋喃 用作溶剂,化学反应 24.0H,以21%的收率获得2-硝基-5-氯苯胺
参考文献:的制备ñ-芳基-小号,小号-Diphenylsulfilimines通过亲核攻击ñ-Lithio-小号,š-Diphenylsulfilimine上的芳族化合物
标题:的制备ñ-芳基-小号,小号-Diphenylsulfilimines通过亲核攻击ñ-Lithio-小号,š-Diphenylsulfilimine上的芳族化合物
摘要:ñ-芳基-小号,小号-Diphenylsulfilimines不寻常的取代模式已经制备由新颖氮亲核反应ñ-Lithio-小号,š-Diphenylsulfilimine与一系列活化的芳族底物.N-Lithio-S,S-二苯基亚硫亚胺不仅能够取代传统的芳族亲核取代反应中的氯基,而且与s(s-S-二苯基亚硫亚胺本身)不同,可以在"毒"的芳族亲核取代基中的含氢位置上发生攻击.氢.
Doi:10.1016/s0040-4020(99)00550-5

专利信息

专利号:EP-1590332-B1
优先权日:2003-01-09
标题:A process for the synthesis of bisbenzimidazoles and their derivatives.
发明人：JAIN AKASH; TAWAR URMILA; CHANDRA RAMESH; DWARAKANATH B S; CHAUDHURY N K; TANDON VIBHA
权利人:UNIV DELHI
摘要:A process for the synthesis of bisbenzimidazoles and its derivations comprising; (i) reacting 5 chloroaniline with zinc dust and acetic anhydride to produce 5 chloroacetanilide; (ii) reacting 5 chloroacetanilide with HN03 to produce 2-nitro-5-chloroacetanilide; (ix) adding sodium methoxide to 2-nitro-5-ch1oroaniline; (x) heating 2-nitro-5-chloroaniline, methyl piperazine, anhydrous K2CO3 and Dimethyl formamide at 100-120°C produce a mixture which is cooled by pouring ice and is filtered to obtain 5-(4'-methylpiperazin-1'-yl)-2-nitroaniline; (xi) treating 5-(4'-methylpiperazin-l'yl)-2-nitroaniline with Pd/C to produce 2-amino-4-(4'-methylpiperazin-1'-yl) aniline; (xii) refluxing a mixture of 2-amino-4-(4'-methylpiperazin-1'yl) aniline and ethyl-4-amino-3-nitrobenzenecarboximidate hydrochloride in presence of ethanol/glacial acetic acid to produce 4-[5'-(4'-methylpiperazin-1'-yl) 15 benzimidazol-2'-yl)-2-nitroaniline; (xiii) treating a solution of 4-[5'-(4'-methylpiperazin-1'-yi) benzimidazol-2'-yl)-2-nitroaniline with palladium on carbon to yield 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline; (xiv) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline and 3-4-dimethoxy benzaldehyde using nitrobenzene as a solvent at 110-150°C to produce (DMA) i.e 5-(4-methylpiperazin-1-yl)-2-[2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl] benzimidazole; (ix) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl) benzimidazol-2'-YI] aniline and 5-Formyl-[3-methoxy-4-hydroxy benzimidazole] using nitrobenzene at 110°C to 150°C in presence of argon to produce (TBZ) i.e 5-(4-methylpiperazine-1-yl)-2-[2' (2'-(4-hydroxy-3methoxyphenyl)5'benzimidazolyl) -5'- benzimidazolyl] benzimidazole.

专利号:US-6753347-B2
优先权日:1999-06-28
标题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof
发明人：KISHI NAOYUKI; NAKAMURA YOSHITAKA; ABE NARUMI; TAKEBAYASHI TOYONORI
权利人:SANKYO CO
摘要:This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, n wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, etc., R 2 is C 1 -C 6 alkyl, and R 3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.

专利号:US-2003199580-A1
优先权日:1999-06-28
标 题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof

专利号:US-9603950-B1
优先权日:2015-10-25
标题 :Compounds of imaging agent with HDAC inhibitor for treatment of Alzheimer syndrome and method of synthesis thereof
发明人：LI MING-HSIN; SHIUE CHYNG-YANN; CHANG HAN-CHIH; CHU HAN-HSIANG
权利人:LI MING-HSIN; SHIUE CHYNG-YANN; CHANG HAN-CHIH; CHU HAN-HSIANG; INST NUCLEAR ENERGY RES
摘要:A method of synthesizing a compound of imaging agent with HDAC (histone deacetylase) inhibitor consists of two parts, the first part of the method is to provide the inhibitor of HDAC with a compound of imaging agent that includes HDAC inhibitor BNL-26 (C 22 H 23 N 3 O) and its analogs to be labeled with radionuclide F-18, producing a series of new nuclear medicine tracers: BNL-26-CH 2 CH 2 18F, BNL-26a-CH 2 CH 2 18FF, BNL-26b-CH 2 CH 2 18F, BNL-26c-CH 2 CH 2 18F and BNL-26d-CH 2 CH 2 18F. These nuclear medicine with imaging agents can be used as a tracer in vivo binding to over-expression HDAC and produce a HDAC nuclear medicine imaging effect to serve for clinical diagnosis. The second part of the method is to provide a slightly adjusted a structural framework of BNL-26 and use pyridine to substitute the benzene ring of the BNL-26 structure, and then synthesize with other substituent to produce a series of additional 30 more HDAC inhibitors, named from Iner-1 to Iner-30 compounds.

专利号:EP-1590332-A1
优先权日:2003-01-09
标题:A process for the synthesis of bisbenzimidazoles and its derivations

专利号:AT-E530533-T1
优先权日:2005-05-17
标 题 :METHOD FOR SYNTHESIS OF HETEROCYCLIC COMPOUNDS