CAS: 17321-47-0; O,O-Dimethyl Phosphoramidothioate

上下游产品

dimethyl chlorothiophosphate sodium methylate R)-3,4c-dimethyl-5c-phenyl-2-thioxo-2λ5-[1,3,2]oxazaphospholidin-2r-ylamine(2R)-3,4c-dimethyl-5c-phenyl-2-thioxo-2λ5-[1,3,2]oxazaphospholidin-2r-ylamineMio O,O-dimethyl N-acetylphosphoramidothioate O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate O,O-dimethyl 3-(trifluoromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate

二甲基硫代磷酰氯置于ammonium Hydroxide体系中,用 二氯甲烷 用作溶剂,以99%的收率获得精胺
参考文献:某些硫代氨基磷酰胺农药的合成,光谱表征及构效关系
标题:某些硫代氨基磷酰胺农药的合成,光谱表征及构效关系
摘要:在这项工作中,一些通式为(ch 3 O)2 P(S)x和(ch 3 O)(ch 3 S)p(o)x的硫代氨基磷酰胺(pat),其中x = Nh 2(1&6),Nh(ch 3)(2&7),N(ch 3)2(3&8),N(et)2(4&9),(ch 3 Ch 2 O)2 P(S) Nh(ch 3)(5)和(ch 3 Ch 2合成了o)(ch 3 Ch 2 S)p(o)nh(ch 3)(10),并通过31 P,31 P { 1 H},13 C和1 H NMR光谱进行了表征.通过pass软件(1.193版)预测了化合物抑制ache的能力.还通过改良的ellman分析法对它们进行了实验评估.研究了ic50与某些理化性质(如亲脂性(log P),化合物的电子和空间效应)之间的构效关系(sar).日志p值通过摇瓶(气相色谱法)实验确定.这些化合物的抑制效力1-10为1(3.38毫摩尔)> 2(3.97毫摩尔)>
Doi:10.1007/bf03245903

专利信息

专利号:US-2023339989-A1
优先权日:2020-01-31
标 题 :A continuous flow process for preparation of acephate and its intermediates
发明人：KINI PRASHANT VASANT; SARKAR SUPRATIM ROY
权利人:UPL LTD
摘要:The present invention relates to a continuous flow process for synthesis of acephate and its intermediates. The present invention more particularly relates to synthesis of acephate and its intermediates in a microreactor system.

专利号:US-6127566-A
优先权日:1998-09-16
标 题 :Process for the synthesis of O,O-dimethyl phosphoroamidothioate
发明人：PRASAD VIDYANATHA A; SMITH DONALD K; MEYER DAVID L; SPICHER JONATHAN D; HENSLEY SCOTT P
权利人:BAYER AG
摘要:The present invention provides a continuous process for making O,O-dimethyl phosphoroamidothioate. In accordance with this process, O,O-dimethyl phosphorochloridothioate is reacted with ammonia and sodium hydroxide; addition of the sodium hydroxide controls the pH of the reaction mixture. The formed reaction mixture contains an aqueous phase and an organic phase. The organic phase of the reaction mixture is separated from the aqueous phase; a second organic phase is solvent extracted from the aqueous phase; and the resultant O,O-dimethyl phosphoroamidothioate is isolated from the combined organic phases via vacuum solvent stripping. In an embodiment of the present invention, the reaction of O,O-dimethyl phosphorochloridothioate with ammonia and sodium hydroxide is carried out in the presence of a solvent.

专利号:US-3655835-A
优先权日:1968-05-20
标 题 :Process for the preparation of dimethyl-thiophosphite or of organothiophosphonous acid o-monomethyl ester
发明人：SCHLIEBS REINHARD
权利人:BAYER AG
摘要:REACTING TRIMETHYLPOSPHITE OR ORGANO-PHOSPHONOUS ACID O,O-DIMETHYL ESTER WITH HYDROGEN SULFIDE IN THE PRESENCE OF A WEAK ORGANIC BASE (THE PKA OF WHICH IN AQUEOUS SOLUTION IS ABOT 0.5-8) AT A TEMPERATURE OF SUBSTANTIALLY BETWEEN ABOUT 0-70*C. AND A STARTING PRESSURE OF SUBSTANTIALLY BETWEEN ABOUT 1-65 ATMOSPHERES ABSOLUTE, TO FORM IN HIGH YIELD AND PURITY THE CORRESPONDING KNOWN DIMETHYL-THIOPHOSPHITE OR ORGANO-THIOPHOSPHONOUS ACIDO-MONO METHYL ESTER, WHICH ARE KNOWN INTERMEDIATES USEABLE FOR THE SYNTHESIS OF KNOWN BIOCIDAL, ESPECIALLY INSECTICIDAL, PHOSPHORIC ACID ESTERS.

专利号:US-9458100-B2
优先权日:2012-10-12
标 题:Synthesis and growth regulatory activity of a prototype member of a new family of aminothiol radioprotectors
发明人：FAHL WILLIAM E
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The synthesis, growth inhibition and radioprotective activity of the PrC-210 aminothiol, 3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol, and its polyamine and thiolated polyamine progenitors are reported. All of the molecules significantly inhibited growth of cultured normal human fibroblasts. The combination of an ROS-scavenging thiol group and a positively charged alkyl-amine backbone provided the most radioprotective aminothiol molecule.

专利号:US-2014107216-A1
优先权日:2012-10-12
标 题 :SYNTHESIS AND GROWTH REGULATORY ACTIVITY OF A PROTOTYPE MEMBER OF A NEW FAMILY OF AMlNOTHIOL RADIOPROTECTORS

专利号:US-2014107217-A1
优先权日:2012-10-12
标 题:SYNTHESIS AND GROWTH REGULATORY ACTIVITY OF A PROTOTYPE MEMBER OF A NEW FAMILY OF AMlNOTHIOL RADIOPROTECTORS