2-氯苯甲醚置于氢氟酸,氯体系中,用 四氯化碳 作为反应溶剂,140.0 °C,2.6 Mpa 条件下,反应 16.5H,反应生成 邻氯三氟甲氧基苯 参考文献:Langlois,Bernard; Soula,Gerard,Bulletin De La Societe Chimique De France,1986,# 6,P. 925-929 标题:Langlois,Bernard; Soula,Gerard,Bulletin De La Societe Chimique De France,1986,# 6,P. 925-929
专利号:US-2013184465-A1 优先权日:2010-09-30 标 题:Process for the synthesis of thio-triazolo-group containing compounds 发明人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL 权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE 摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
专利号:US-4157344-A 优先权日:1978-01-16 标题 :Preparation of aryl trifluoromethyl ethers 发明人:FEIRING ANDREW E 权利人:DU PONT 摘要:A one-step process for the synthesis of aryl trifluoromethyl ethers by reacting phenol or certain substituted phenols with a perhalomethane and hydrogen fluoride is provided. The compounds produced by the process of this invention are useful intermediates in the production of dyestuffs and pharmaceuticals.
专利号:US-4446078-A 优先权日:1982-01-21 标 题 :Process for the preparation of α,α-difluoroalkyl-thiophenyl ketones 发明人:DESBOIS MICHEL 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the preparation of alpha , alpha -difluoroalkoxy or alpha , alpha -difluoroalkylthiophenyl ketones, in which a polyhaloalkoxybenzene or a polyhaloalkylthiobenzene is reacted with a carboxylic acid, a precursor or a derivative of this acid in the presence of boron trifluoride in such an amount that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having phytosanitary (e.g., herbicidal) or pharmaceutical activity.
专利号:US-4438043-A 优先权日:1982-04-22 标题:Process for preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones 发明人:DESBOIS MICHEL 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones, characterized in that, in a first stage, a di- or trihalomethoxybenzene or a di- or trihalomethylthiobenzene is reacted with a trihalomethylated aromatic or aliphatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent and in that, in a second stage, the product of the first stage is hydrolyzed. The resultant products are useful as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.
专利号:US-4621160-A 优先权日:1983-06-23 标题 :Process for the chlorination of aromatic derivatives 发明人:DESBOIS MICHEL; DISDIER CAMILLE 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the chlorination of aromatic derivatives. The aromatic derivative is reacted with chlorine gas in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.
专利号:US-2006058525-A1 优先权日:2004-09-01 标题 :Synthesis of 2,4-pyrimidinediamine compounds 发明人:SINGH RAJINDER; ARGADE ANKUSH 权利人:SINGH RAJINDER; ARGADE ANKUSH 摘要:The present invention provides an economical and efficient method to prepare various substituted 2,4-pyrimidinediamine compounds in large scale quantities.
参考标题:Pd-Catalyzed Synthesis Of Piperazine Scaffolds Under Aerobic And Solvent-Free Conditions 作者:Sean W. Reilly,Robert H. Mach |发布日期:2016.10.21 摘要:A Facile Pd-Catalyzed Methodology Providing An Efficient Synthetic Route To Biologically Relevant Arylpiperazines Under Aerobic Conditions Is Reported. Electron Donating And Sterically Hindered Aryl Chlorides Were Aminated To Afford Yields Up To 97%, With Examples Using Piperazine As Solvent, Illustrating An Ecofriendly, Cost-Effective Synthesis Of These Privileged Structures.
合成参考文献
摘要:Yerien, D. E.; Barata-Vallejo, S.; Postigo, A., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 9.