CAS: 49607-01-4; (R)-2-Amino-2-Cyclopropylacetic Acid

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CAS号121703-92-2 N-Chloroacetyl-... | CAS号54256-41-6 N-叔丁氧羰基-环丙基甘氨酸

2-氨基-2-环丙基乙酸甲酯置于papain (From Carica Papaya) 盐酸,Dithiothreitol,Mcilvaine'S Buffer Cont. Edta,盐酸羟胺,Potassium Carbonate体系中,用 1,4-二氧六环,甲醇,水,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 57.0H,反应生成 D-环丙基甘氨酸
参考文献:环丙基甘氨酸和2-环丙基-2-N-Boc-亚氨基乙酸甲酯的对映体的实用合成
标题:环丙基甘氨酸和2-环丙基-2-N-Boc-亚氨基乙酸甲酯的对映体的实用合成
摘要:已详细说明了从便宜的环丙基甲基酮轻松合成三克外消旋环丙基甘氨酸的方法.用来自番木瓜的廉价木瓜蛋白酶酶解环丙基甘氨酸9的n-Boc保护的甲酯,在酸性条件下脱保护后,提供环丙基甘氨酸(8)的两种对映异构体,其对映体过量为99%或更高.此外,通过n制备新的含环丙基基团的2-环丙基-2-N-Boc-亚氨基乙酸甲酯(13)1,8-二氮杂双环[5.4.0]十一碳-7-烯(dbu)进行氯化-氯化反应,然后进行脱氯化氢反应.向13个亲核试剂中添加亲核试剂可方便地获得不寻常的,正交双保护的α,α-二氨基酸衍生物和刚性肽骨架的有趣组分.
DOI:10.1002/adsc.200606038

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2019330618-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries