间溴苯甲腈置于palladium Diacetate,1,3-双(二苯基膦)丙烷 盐酸体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 12.5H,反应生成 3-乙酰苯腈 参考文献:.Alpha.-Regioselectivity In Palladium-Catalyzed Arylation Of Acyclic Enol Ethers 标题:.Alpha.-Regioselectivity In Palladium-Catalyzed Arylation Of Acyclic Enol Ethers 摘要:Regioselective Alpha-Arylation Of Acyclic Enol Ethers By Aryl Trifluoromethanesulfonates,Aryl Bromide,Aryl Iodides,And Aroyl Chlorides Is Described. The Outcome Of The Reaction Proved To Be Dependent From The Relationship Between Ligand And Counterion In The Oxidative Addition Complex. DOI:10.1021/jo00031A029
专利号:US-7951827-B2 优先权日:2005-05-05 标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles 发明人:TIDWELL RICHARD R; BAKUNOVA SVETLANA M; BAKUNOV STANISLAV; PATRICK DONALD A 权利人:UNIV NORTH CAROLINA 摘要:Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.
专利号:AU-3213599-A 优先权日:1998-04-03 标 题:A convergent synthesis of alpha-aryl-beta-ketonitriles
专利号:US-2006264487-A1 优先权日:2005-05-05 标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
专利号:US-8513241-B2 优先权日:2008-03-28 标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them 发明人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA 权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL 摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
专利号:AU-2006201739-A1 优先权日:2005-05-05 标题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
专利号:EP-1719767-A1 优先权日:2005-05-05 标题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
[参考文献]: C Y Watson, Et Al. Synthesis Of 3-Substituted Benzamides And 5-Substituted Isoquinolin-1(2H)-Ones And Preliminary Evaluation As Inhibitors Of Poly(Adp-Ribose)Polymerase (Parp). Bioorg Med Chem. 1998 Jun;6(6):721-34.
合成参考文献
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