Diethyl 2,2'-Disulfanediyldiacetate置于乙醇,二硝酚体系中,化学反应生成 巯基乙酸乙酯 参考文献:Obata; Yamanishi,Bulletin Of The Chemical Society Of Japan,1949,Vol. 22,P. 248,249 标题:Obata; Yamanishi,Bulletin Of The Chemical Society Of Japan,1949,Vol. 22,P. 248,249
专利号:US-2004106829-A1 优先权日:2002-11-12 标题 :Process for the synthesis of modafinil 发明人:FORNAROLI MIRCO; VELARDI FRANCESCO; COLLI CORRADO; BAIMA ROBERTO 权利人:PROCOS SPA 摘要:The present invention relates to a process for the preparation of 2-(benzhydrylthio)acetamide (II), key intermediate for the synthesis of modafinil, by reaction of benzhydryl chloride with thiourea and chloroacetamide.
专利号:US-5922910-A 优先权日:1997-08-27 标 题 :Synthesis of carboxyalkylthiosuccinic acids 发明人:LABAT YVES; MULLER JEAN-PIERRE 权利人:ATOCHEM ELF SA 摘要:Process for the preparation of a carboxyalkylthiosuccinic acid of formula ##STR1## in which n=1 to 3 and Râ•?H or CH 3 , a mercapto ester of formula HS--(CH 2 ) n --COOR' in which R' is a C 1 to C 4 alkyl radical, is reacted, in aqueous medium and without a catalyst, with maleic acid, citraconic acid or their anhydride. The invention is more particularly directed towards the preparation of carboxyethylthiosuccinic acid (CETSA).
专利号:US-4500535-A 优先权日:1979-10-15 标 题:Method of regulating the immune response with pyridine derivatives 发明人:LOMBARDINO JOSEPH G; HARBERT CHARLES A 权利人:PFIZER 摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)-pyridine [alternatively named 2-(4-picolylthio)acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.
专利号:US-6472488-B2 优先权日:1997-02-13 标 题 :(Thio) (meth) acrylate monomers, intermediate compounds for the synthesis of these monomers, polymerizable compositions and polymers obtained, and their optical and ophthalmic uses 发明人:CAYE FLORENCE; SINDT MICHELE; PAQUER DANIEL; JURY DOROTHEE; SCHNEIDER MICHEL; MIELOSZYNSKI JEAN-LUC 权利人:ESSILOR INT 摘要:Polymerizable compositions from novel monomers that correspond to the formula: n in which: n Z represents H or CH 3 and X represents O or S, and n Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.
专利号:US-11590142-B2 优先权日:2018-03-28 标题 :Oxazolidinone antibiotic compounds and process of preparation 发明人:PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA; RAMACHANDRAN VASANTHI 权利人:BUGWORKS RES INC 摘要:Compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments are provided. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by microbes. Methods for the synthesis and characterization of the aforementioned substances are also provided.
专利号:US-9868747-B2 优先权日:2014-02-18 标题:Marinopyrrole derivatives and methods of making and using same 发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI 权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD 摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
[参考文献]: Timothy M O'Shea, Et Al. Covalent Incorporation Of Trehalose Within Hydrogels For Enhanced Long-Term Functional Stability And Controlled Release Of Biomacromolecules. Adv Healthc Mater. 2015 Aug 26;4(12):1802-12.
合成参考文献
摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2014) 3, 105. 摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2014) 3, 87. 摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 68. 摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 320. 摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 293.