CAS: 691877-03-9; 3-Bromo-5-(Trifluoromethyl)Benzonitrile

上下游产品

CAS号49674-28-4 3-氨基-5-氰基三氟甲苯 | CAS号691877-04-0 (3-bromo-5-(tri...

3-氨基-5-氰基三氟甲苯置于亚硝酸特丁酯,Copper(Ll) Bromide体系中,用 乙腈 作为反应溶剂,以59.3%的收率获得产物5-三氟甲基-3-溴苯腈
参考文献: Gamma-Aminoamide Modulators Of Chemokine Receptor Activity[fr] Modulateurs Gamma-Aminoamides De L'Activite De Recepteur De Chimiokine
标题: Gamma-Aminoamide Modulators Of Chemokine Receptor Activity[fr] Modulateurs Gamma-Aminoamides De L'Activite De Recepteur De Chimiokine
摘要:本发明涉及式(I)的化合物,其中r1,R2,R3,R4,R5,R6,R7,R8,R11,R12,W,X和n在此处定义,这些化合物可用作趋化因子受体活性的调节剂.特别是,这些化合物可用作趋化因子受体ccr-2的调节剂.

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.