(文献来源)合成步骤主要原料 Isopentylmagnesium Bromide Solution 2 In Diethyl Ether
Magnesium,2-Methylbutane,Bromide置于硫酸体系中,用 乙醚 作为反应溶剂,化学反应生成 3-甲基-1-丁基硼酸 参考文献:P1 Phenethyl Peptide Boronic Acid Inhibitors Of Hcv Ns3 Protease 标题:P1 Phenethyl Peptide Boronic Acid Inhibitors Of Hcv Ns3 Protease 摘要:A Series Of Peptide Boronic Acids Containing Extended,Hydrophobic P1 Residues Was Prepared To Probe The Shallow,Hydrophobic S1 Region Of Hcv Ns3 Protease. The P-Trifluoromethylphenethyl P1 Substituent Was Identified As Optimal With Respect To Inhibitor Potency For Ns3 And Selectivity Against Elastase And Chymotrypsin. (C) 2002 Published By Elsevier Science Ltd. DOI:10.1016/s0960-894X(02)00682-0
专利信息
专利号:US-8207337-B2 优先权日:2007-01-29 标 题:Reagent for organic synthesis reaction containing organic triol borate salt 发明人:MIYAURA NORIO; YAMAMOTO YASUNORI 权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD 摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).
专利号:EP-4008721-B1 优先权日:2004-03-30 标 题:Synthesis of boronic ester and acid compounds
专利号:EA-012927-B1 优先权日:2004-03-30 标 题 :SYNTHESIS OF BORONIC ACID ETHERS AND ACID COMPOUNDS
专利号:US-2022204558-A1 优先权日:2004-03-30 标题 :Synthesis of boronic ester and acid compounds
专利号:EP-4008721-A1 优先权日:2004-03-30 标题:Synthesis of boronic ester and acid compounds