CAS: 98929-98-7; Fmoc-His(Fmoc)-Oh

相似化合物

109425-51-6 123333-71-1 135610-90-1

专利信息

专利号:US-5602231-A
优先权日:1991-06-14
标题 :Process for making peptides
发明人：COTTON RONALD; GILES MICHAEL B
权利人:ZENECA LTD
摘要:A process for the solid phase synthesis of peptides containing a C-terminal aza-amino acid, for example the decapeptide goserelin, which comprises: (i) reacting an active ester or imidazolide of an N-protected aza-amino acid either with an appropriate reactive solid support in the case of the synthesis of a peptide containing a C-terminal aza-amino acid, or with a peptide which is attached to a solid support in the case of the synthesis of a peptide containing a non-C-terminal aza-amino acid; (ii) carrying out further conventional solid phase peptide synthesis steps to add sequentially further amino acids, to form a peptide with the required amino acid sequence bound to the solid support; (iii) cleaving the peptide from the solid support, and optionally (iv) reacting the product so formed with hydrazine to remove any acyl groups which have been formed on serine, arginine, tyrosine, threonine or hydroxyproline during the synthesis.

专利号:US-5510460-A
优先权日:1991-06-14
标 题:Peptide process
发明人：HAYWARD CHRISTOPHER F
权利人:ZENECA LTD
摘要:A process for the solid phase synthesis of peptides containing an aza-amino acid, for example the decapeptide goserelin, which comprises: (i) assembling all the amino acids of the peptide except the C-terminal aza-amino acid by conventional solid phase synthesis; (ii) cleaving the peptide from the support with hydrazine or a substituted hydrazine; and (iii) reacting the hydrazide thus released with a cyanate ion.

专利号:JP-3176710-B2
优先权日:1991-06-14
标 题:Solid phase synthesis of peptides containing C-terminal azaamino acid amides

专利号:NO-303390-B1
优先权日:1991-06-14
标 题 :A process for solid phase synthesis of a peptide containing at least one aza amino acid

专利号:CN-104910257-A
优先权日:2015-01-07
标 题:The solid-phase synthesis method of goserelin acetate

专利号:JP-H05170795-A
优先权日:1991-06-14
标题:Solid-phase synthesis method of peptide containing C-terminal azaamino acid amide