合成目标产物 Triethanolamine 主要起始原料 Ethylene Oxide And Monoethanolamine
(文献来源)合成步骤主要原料 Ethylene Oxide 和 Monoethanolamine
Sodium Chlorite 反应生成三乙醇胺 参考文献:Aqueous Composition And Method Of Producing Chlorine Dioxide Using Aqueous Composition 标题:Aqueous Composition And Method Of Producing Chlorine Dioxide Using Aqueous Composition 摘要:一种水性组合物包括一个活化剂,一个亚氯酸盐离子源和水.该水性组合物呈碱性.该水性组合物在与酸接触时产生二氧化氯.生产二氧化氯的方法包括将水性组合物与酸接触.
专利信息
专利号:US-12383499-B2 优先权日:2018-01-01 标题:Scale up synthesis of silicasome nanocarriers 发明人:NEL ANDRE E; MENG HUAN; LIU XIANGSHENG 权利人:UNIV CALIFORNIA 摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).
专利号:US-9561498-B2 优先权日:2012-04-27 标 题 :Process for the direct synthesis of Cu-SAPO-34 发明人:FRANCO RAQUEL MARTINEZ; MARIN MANUEL MOLINER; CANÓS AVELINO CORMA; KUSTOV ARKADY; THØGERSEN JOAKIM REIMER 权利人:FRANCO RAQUEL MARTINEZ; MARIN MANUEL MOLINER; CANÓS AVELINO CORMA; KUSTOV ARKADY; THØGERSEN JOAKIM REIMER; HALDOR TOPSOE AS 摘要:A process for the direct synthesis of Cu-SAPO-34 comprising at least the steps: preparation of a mixture of water, at least one silicon source, at least one Al source, at least one P source, at least one Cu source, at least one 0SDA1 (any polyamine), and at least one OSDA2 source (where OSDA2 is any organic molecule capable of directing the synthesis of SAPO 34); and where the final synthesis mixture has the molar composition: a Si:0.5 Al:c Cu:d OSDA1:e OSDA2:f H2O wherein a is in the range from 0.01 to 0.3; b is in the range from 0.2 to 0.49; c is in the range from 0.001 to 0.6; d is in the range from 0.001 to 0.6; e is in the range from 0.001 to 2; f is in the range 1 to 200; hydrothermal treatment of the mixture at 80−200° C. until formation of the crystalline material, and recovery of the crystalline material.
专利号:US-2021130543-A1 优先权日:2019-10-30 标 题:Synthesis of cyanurate and multifunctional alcohol-based polyether acrylate for uv curable materials 发明人:YUAN ZHONGSHUN; XU CHUNBAO; WU WEI 权利人:YUAN ZHONGSHUN; XU CHUNBAO; WU WEI 摘要:Polyether (meth)acrylates based on cyanuric acid or substituted cyanuric acid and multifunctional alcohol, which optionally include triethanolamine units, have wide applications in UV curable adhesives, coatings, inks, sealants, paints or 3D printing. These polyether acrylates have rigid cyanurate structure endowing the material with extra strength and thermal stability. Furthermore, triethanolamine unit, when present, endows the material with anti-oxygen inhibition property in UV curing process. These polyether (meth)acrylates have low viscosity and high reactivity towards UV curing. The cured resins have high resilience and strength. The process of making the polyether (meth)acrylates includes the synthesis of trifunctional polyether polyols through controlled polymerization of propylene oxide using multifunctional alcohol (such as glycerol and sucrose), cyanuric acid or substituted cyanuric acid, and optionally triethanolamine, in the presence of a catalyst, followed by the synthesis of polyether (meth)acrylates through transesterification or through direct esterification of the trifunctional polyether polyols.
专利号:US-3963770-A 优先权日:1972-09-27 标 题:Synthesis of ortho-chlorobenzalmalononitrile 发明人:KNAPP JOHN S 权利人:FEDERAL LAB INC 摘要:Disclosed herein is a synthesis of ortho chlorobenzalmalononitrile by reacting malononitrile with ortho-chloro benzaldehyde in methanol in the presence of a basic catalyst; separating the product crystals from the methanol; washing the crystals with fresh methanol; combining the wash methanol with the methanol filtrate and using the combined methanol in another similar synthesis run and repeating a series of such runs; drying the crystals with a current of turbulent dry air and scrubbing the air with base solution thereby substantially reducing associated problems of effluent treatment and ambient air pollution.
专利号:US-9278972-B2 优先权日:2011-12-23 标题 :Synthesis of triazolopyrimidine compounds 发明人:MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.
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合成参考文献
参考文献:10.1021/bm100007s 摘要:Pang Y, Zhu Q, Liu J, Wu J, Wang R, Chen S, Zhu X, Yan D, Huang W, Zhu B. Design and synthesis of cationic drug carriers based on hyperbranched poly(amine-ester)s. Biomacromolecules. 2010 Mar 08;11(3):575–82. doi: 10.1021/bm100007s. 参考文献:10.1016/j.ijpharm.2010.02.014 摘要:Dicko A, Kwak S, Frazier AA, Mayer LD, Liboiron BD. Biophysical characterization of a liposomal formulation of cytarabine and daunorubicin. International Journal of Pharmaceutics. 2010 May;391(1-2):248–59. doi: 10.1016/j.ijpharm.2010.02.014. 参考文献:10.1007/s10295-005-0062-3 摘要:Liu Y, Sha Q, Wu S, Wang J, Yang L, Sun W. Enzymatic resolution of racemic phenyloxirane by a novel epoxide hydrolase from Aspergillus niger SQ-6 and its fed-batch fermentation. Journal of Industrial Microbiology & Biotechnology. 2005 Dec 01;33(4):274–82. doi: 10.1007/s10295-005-0062-3. 参考文献:10.1208/s12249-011-9661-7 摘要:Badıllı U, Sen T, Tarımcı N. Microparticulate based topical delivery system of clobetasol propionate. AAPS PharmSciTech. 2011 Sep;12(3):949–57. 参考文献:10.4137/aci.s6969 摘要:Salem AA, Soliman AA, El-Haty IA. New spectrophotometric method for determining nitrogen dioxide in air using 2,2-azino-bis(3-ethyl benzothiazoline)-6-sulfonic acid-diammonium salt and passive sampling. Anal Chem Insights. 2011;6():37–44.