CAS: 111974-72-2; Quetiapine (Hemifumarate)

上下游产品

(2E)-but-2-enedioic acid Quetiapine 11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydr°Chloride 2-(2-Chloroethoxy)ethanol2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-1-ethyl ethanol

专利信息

专利号:US-7071331-B2
优先权日:2003-02-22
标 题 :Synthesis of quetiapine and pharmaceutically acceptable salts thereof
发明人：DILLER DOV; DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:Provided is a novel synthesis of quetiapine employing phase transfer catalyst.

专利号:WO-2006135544-A1
优先权日:2005-06-10
标 题 :SYNTHESIS OF 11-(4[-(2-HYDROXYETHOXY)ETHYL]-PIPERAZINYL)-DIBENZO[b,f][1,4]THIAZEPINE AND ITS FUMARATE SALT
发明人：BUENGER GREG STEVEN; ALEXANDER ANATOLY
权利人:CAMBREX CHARLES CITY INC; BUENGER GREG STEVEN; ALEXANDER ANATOLY
摘要:The invention is directed a method for synthesizing l l-(4-[2-(2- hydroxyethoxy)ethyl]-piperazinyl)-dibenzo[b,f] [l,4]thiazepine (quetiapine) and for recovering quetiapine as its fumarate salt in which dibenzo[b,f][l,4]thiazepine- l l(10H)one is chlorinated in the presence of a trialkyl amine base using a slight molar excess of phosphorous oxychloride to produce l l-chloro-dibenzo[b,f] [l,4]thiazepine which then is alkylated with piperazine to l l-piperazinyldibenzo[b,f] [l,4]thiazepine, which finally is alkylated with 2-(2-chloroethoxy)ethanol.

专利号:WO-2010001407-A2
优先权日:2008-06-05
标 题:Synthesis of 11-(4-[2-(2-hydroxyethoxy)ethyl]- piperazinyl)dibenzo[b,f][1,4]thiazepine and its fumarate salt

专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates

专利号:US-2008241949-A1
优先权日:2007-03-29
标 题 :Process for preparing quetiapine fumarate
发明人：KANSAL VINOD KUMAR; AHMAD SUHAIL; LAL KANHAIYA; PATIL BHATU TUMBA
权利人:KANSAL VINOD KUMAR; AHMAD SUHAIL; LAL KANHAIYA; PATIL BHATU TUMBA
摘要:Provided is an improved synthesis of quetiapine and pharmaceutically acceptable salts.

专利号:US-2004220400-A1
优先权日:2003-02-22
标题:Synthesis of quetiapine and pharmaceutically acceptable salts thereof