专利号:US-2002015965-A1 优先权日:2000-07-27 标题:Efficient synthesis of triboluminescent lanthanide complexes 发明人:SWEETING LINDA MARIE 摘要:Lanthanide complexes of β-diketonates which incorporate amines or their salts have been shown to exhibit intense photoluminescence and triboluminescence. These triboluminescent materials show a great deal of promise for remote sensing of strain, impact, pressure and fracture. The present invention is a new and more efficient process for synthesizing and testing triboluminescent and photoluminescent materials.
专利号:US-10844088-B2 优先权日:2011-07-19 标 题:Process for the preparation of estetrol 发明人:PLATTEEUW JOHANNES JAN; COELINGH BENNINK HERMAN JAN TIJMEN; DAMEN FRANCISCUS WILHELMUS PETRUS; VAN VLIET MICHIEL CHRISTIAN ALEXANDER 权利人:DONESTA BIOSCIENCE B V; ESTETRA SPRL 摘要:The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3, 15a, 16a, 17β-tetraol (estetr-01), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10), 16-tetraene, wherein A is a protecting group and B is —Si(R 2 ) 3 . The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10), 15-tetraen-17-one, in which A is a protecting group, via silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, and B is —Si(R 2 ) 3 .
专利号:US-7902196-B2 优先权日:2005-03-17 标 题 :Synthesis of avrainvillamide, strephacidin B, and analogues thereof 发明人:MYERS ANDREW G; HERZON SETH B; WULFF JEREMY EARLE; SIEGRIST ROMAIN; SVENDA JAKUB; ZAJAC MATTHEW ALLEN 权利人:HARVARD COLLEGE 摘要:The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.
专利号:US-7105637-B2 优先权日:2002-02-15 标题 :Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis 发明人:SHACKLETON CEDRIC; GUO LI-WEI; WILSON WILLIAM K 权利人:CHILDRENS HOSP & RES CT OAK 摘要:The invention provides isolated dehydro-estriol (8-DHE 3 ) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS).
专利号:US-2009143581-A1 优先权日:2005-03-17 标题 :Synthesis of avrainvillamide, strephacidin b, and analogues thereof
专利号:CA-2601135-A1 优先权日:2005-03-17 标 题 :Synthesis of avrainvillamide, stephacidin b, and analogues thereof
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