CAS: 151169-74-3; 2,3-Dichlorophenylboronic Acid

相似化合物

1255760-30-5 212779-19-6 352530-21-3

上下游产品

CAS号121-43-7 硼酸三甲酯 | CAS号56961-77-4 1-溴-2,3-二氯苯 | CAS号41464-49-7 2,3,3'5'-四氯联苯 | CAS号60145-20-2 2,2',3,3',5-五氯联苯 | CAS号41464-51-1 2,2’,3’,4,5-戊氯联苯 | CAS号38444-78-9 2,2',3-三氯联苯 | CAS号212138-75-5 2-(2,4-dichloro... | CAS号36556-50-0 2,3-二氯氟苯

硼酸三甲酯,2,3-二氯溴苯置于正丁基锂体系中,用 四氢呋喃,正己烷,水,Petroleum Ether 用作溶剂,以8.42 G (50%)的收率获得2,3-二氯苯硼酸
参考文献:Pyrazine Compounds
标题:Pyrazine Compounds
摘要:式(i)的化合物,其中r1选自苯基,该苯基被一个或多个卤素原子取代,萘基和该萘基被一个或多个卤素原子取代的基团;R2选自-nh2和-nhc(═o)Ra的基团;R3选自-nrbrc,-nhc(═o)Ra和氢的基团;R4选自氢,-C1-4烷基,-C1-4烷基被一个或多个卤素原子取代,-cn,-ch2Oh,-ch2Ord和-ch2S(O)Xrd的基团;其中ra代表c1-4烷基或c3-7环烷基,Rb和rc(可以相同也可以不同)选自氢和c1-4烷基,或者与它们连接的氮原子一起形成一个含氮的6元杂环,该杂环可以进一步用一个或多个c1-4烷基取代;Rd选自c1-4烷基或c1-4烷基被一个或多个卤素原子取代;X是整数零,一或二;以及其药学上可接受的衍生物;但是r1不代表(a);当r2为-nh2且r3和r4均为氢时.

专利信息

专利号:US-2023010886-A1
优先权日:2019-09-23
标 题 :Shp2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SUZHOU PUHE BIOPHARMA CO LTD
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-10561655-B2
优先权日:2018-03-21
标 题 :SHP2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SYNBLIA THERAPEUTICS INC
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-6872745-B2
优先权日:2000-04-14
标 题 :Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：JOHNSON JR THEODORE O; HUA YE; LUU HIEP T; DRAGOVICH PETER S
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:WO-2024068976-A1
优先权日:2022-09-29
标 题 :Azole derivatives as shp2 inhibitors
发明人：PETROCCHI ALESSIA; MONTALBETTI CHRISTIAN; DI FABIO ROMANO; CIAMMAICHELLA ALINA; ROSSETTI ILARIA
权利人:IRBM S P A; C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING
摘要:The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.

专利号:US-12233062-B2
优先权日:2018-09-26
标 题 :Heterocyclic derivatives useful as SHP2 inhibitors
发明人：HAN HUIFENG; GAO PANLIANG; MA CUNBO; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.