CAS: 19132-06-0; (2S,3S)-Butane-2,3-Diol

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CAS号431-03-8 2,3-丁二酮 | CAS号513-86-0 3-羟基-2-丁酮 | CAS号57495-46-2 (-)-1 4-二-o-甲苯磺... | CAS号37002-45-2 (-)-1,4-二-O-甲苯磺... | CAS号73136-10-4 Lg-threo-2,3-di... | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号87-69-4 酒石酸 | CAS号6982-25-8 2,3-丁二醇

2,3-丁二醇 反应生成(2S,3S)-(+)-2,3-丁二醇
参考文献:Sequential Kinetic Resolution Of (+/-)-2,3-Butanediol In Organic Solvent Using Lipase From Pseudomonas Cepacia.
标题:Sequential Kinetic Resolution Of (+/-)-2,3-Butanediol In Organic Solvent Using Lipase From Pseudomonas Cepacia.
摘要:Lipase From Pseudomonas Cepacia (Pcl,Amano Ps) Catalyzed The Enantioselective Diacetylation Of (+/-)-2,3-Butanediol In Vinyl Acetate. Both Acetylation Steps Favored The (R)-Enantiomer (E1 = 12,E2 = 34),Thus The Reaction Is A Sequential Kinetic Resolution. The Enantioselectivities Of The Two Steps Reinforced One Another Because Both Steps Proceeded At Comparable Rates (S = 3) Yielding An Overall Enantioselectivity Of Approximately 200. A Synthetic-Scale Resolution Starting From 2.7 G Of (+/-)-2,3-Butanediol Yielded The Diacetate Ester Of (R)-(-)-Butanediol With 96% Ee (1.6 G,30% Yield) And (S)-(+)-Butanediol With 99% Ce (0.63 G,23% Yield). This Preparation Is Carried Out Entirely In Organic Solvent,Thereby Avoiding The Difficult And Low Yield Extraction Of 2,3-Butanediol From Aqueous Solution.
Doi:10.1016/s0957-4166(00)82248-X

专利信息

专利号:US-9862745-B2
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds
发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

专利号:US-8236960-B2
优先权日:2004-09-27
标 题 :Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
发明人：THYGESEN MIKKEL BOAS; SCHLIENGER NATHALIE; TOLF BO-RAGNAR; ANDERSSON CARL-MAGNUS A; BLATTER FRITZ; BERGHAUSEN JOERG
权利人:THYGESEN MIKKEL BOAS; SCHLIENGER NATHALIE; TOLF BO-RAGNAR; ANDERSSON CARL-MAGNUS A; BLATTER FRITZ; BERGHAUSEN JOERG; ACADIA PHARM INC
摘要:Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.

专利号:US-2017349919-A1
优先权日:2014-12-19
标题 :Micro-organism for the production of stereo-specific s, s-2,3-butanediol
发明人：SOLEM CHRISTIAN; JENSEN PETER RUHDAL; CHEN JUN; LIU JIANMING
权利人:UNIV DANMARKS TEKNISKE
摘要:The invention relates to a genetically modified lactic acid bacterium capable of producing (S,S)-2,3-butanediol stereo specifically from glucose under aerobic conditions. Additionally the invention relates to a method for producing (S,S)-2,3-butanediol and L-acetoin using the genetically modified lactic acid bacterium, under aerobic conditions in the presence of a source of iron-containing porphyrin or a source of metal ions (Fe 3+ /Fe 2+ ). The lactic acid bacterium is genetically modified to express heterologous genes encoding enzymes catalysing the stereo-specific synthesis of (S,S)-2,3-butandiol; and additionally a number of genes are deleted in order to maximise the production of (S,S)-2,3-butanediol as compared to other products of oxidative fermentation.

专利号:US-6271195-B1
优先权日:1992-06-30
标题:Aminimide-containing molecules and materials as molecular recognition agents
发明人：HOGAN JOSEPH C JR
权利人:ARQULE INC
摘要:The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

专利号:US-2018265546-A1
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds

专利号:US-2023357137-A1
优先权日:2020-05-06
标题:Synthesis of Sulfonamide Intermediates