专利号:US-11427530-B2 优先权日:2018-02-09 标 题 :Synthesis of 4-chlorokynurenines and intermediates 发明人:LEVIN DANIEL; LEEMING PETER; EISENREICH EMERICH; LIU XUEJUN KARL 权利人:VISTAGEN THERAPEUTICS INC 摘要:The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.
专利号:US-8461357-B2 优先权日:2008-09-19 标题 :Expeditious synthesis of gibberellin A5 and esters thereof 发明人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS RICHARD P 权利人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS R P; UTI LIMITED PARTNERSHIP 摘要:An expeditious synthesis of gibberellin A 5 (GA 5 ) esters is presented, from which GA 5 may be prepared. The synthesis offers an inexpensive route of few steps to these compounds, starting from gibberellin A 3 (GA 3 ) esters in the presence of a metal hydride.
专利号:US-4287123-A 优先权日:1980-01-14 标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate 发明人:LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER 权利人:MERCK & CO INC 摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.
专利号:US-4282148-A 优先权日:1980-01-14 标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid 发明人:LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER 权利人:MERCK & CO INC 摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.
专利号:US-4414155-A 优先权日:1980-01-14 标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid 发明人:LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER 权利人:MERCK & CO INC 摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.
专利号:US-4269772-A 优先权日:1980-01-14 标 题 :Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline 发明人:MELILLO DAVID G; RYAN KENNETH M 权利人:MERCK & CO INC 摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R5 and R6 are removable protecting groups.
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合成参考文献
摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 242. 摘要:Łyżwa, P., Science of Synthesis Knowledge Updates, (2011) 2, 490. 摘要:Łyżwa, P., Science of Synthesis Knowledge Updates, (2011) 2, 480. 摘要:Łyżwa, P., Science of Synthesis Knowledge Updates, (2011) 2, 486. 摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 243.