CAS: 20870-78-4; 5-Bromoindolin-2-One

上下游产品

CAS号59-48-3 2-吲哚酮 | CAS号87-48-9 5-溴靛红 | CAS号18108-55-9 1-hydroxy-3H-in... | CAS号65816-14-0 1,3-dihydro-1-M... | CAS号91-56-5 靛红 | CAS号79-04-9 氯乙酰氯 | CAS号106-40-1 对溴苯胺 | CAS号5461-32-5 2-硝基苯基丙酮酸 | CAS号42366-35-8 (2E)-2-(Hydroxy... | CAS号873779-30-7 5-溴-2-氧代螺[二氢吲哚-... | CAS号837392-64-0 5-硼酸频那醇酯吲哚-2-酮 | CAS号142273-20-9 肯帕罗酮 | CAS号304468-42-6 5'-溴-1',2'-二氢螺[... | CAS号848649-91-2 5-溴-1,3-二氢-2H-吲... | CAS号90725-49-8 5-溴-3-甲基-2,3-二氢... | CAS号920023-48-9 1,2-DIHYDRO-2-O...

2-吲哚酮置于n-Chloro-N-Fluorobenzenesulfonamide,Potassium Bromide体系中,用 乙腈 用作溶剂,化学反应 0.33H,以90%的收率获得5-溴氧化吲哚
参考文献:使用cfbsa / Kbr系统进行快速,温和和有效的溴化†
标题:使用cfbsa / Kbr系统进行快速,温和和有效的溴化†
摘要:溴化是有机化学中的一个基本转变,而溴化化合物则是有机合成中最重要的组成部分.在我们的研究中,我们通过在室温下以短反应时间使用cfbsa / Kbr系统开发了一种有效的溴化方法.值得注意的是,该方法已被证明适用于一系列底物,包括1,3-二酮和β-酮酯,苯酚,芳族胺和杂芳烃,具有非常好或优异的收率.
Doi:10.1039/c6Ra20217A

专利信息

专利号:US-2008319204-A1
优先权日:2007-06-25
标题 :Process for the synthesis of progesterone receptor modulators
发明人：WU YANZHONG; SUTHERLAND KAREN; CONSIDINE JOHN LEO; WILK BOGDAN KAZIMIERZ; GIGUERE PIERRE; MACEWAN MICHAEL; SHARMA ARCHANA; GONTCHAROV ALEXANDER
权利人:WYETH CORP
摘要:Processes for preparing substituted oxindole-2-ones, and specifically the following, are described, wherein R 1 -R 4 , R 6 , and n are defined herein. The processes include reacting a first alkali metal hydroxide, a tetraalkyl ammonium salt, a benzonitrile, and R 6 X or XCH 2 (CH 2 ) n X′, wherein R 6 is C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 3 to C 8 cycloalkyl, substituted C 3 to C 8 cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, or substituted heterocyclic, X and X′ are, independently, leaving groups, and n is 1 to 5; (ii) reacting the product of step (i) with a second alkali metal hydroxide at a temperature of at least about 60° C.; (iii) reacting the product of step (ii) with an alkali alkoxide at a temperature of at least about 140° C. to form an oxindol-2-one; (iv) brominating the oxindol-2-one; and (v) coupling the brominated oxindol-2-one with a coupling reagent.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-2004067531-A1
优先权日:1997-08-20
标 题:Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
发明人：TANG PENG CHO; SUN LI; TRAN NGOC MY; NGUYEN ANH THI; NEMATALLA ASAAD
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:US-6514981-B1
优先权日:1998-04-02
标题:Methods of modulating tyrosine protein kinase function with indolinone compounds
发明人：TANG PENG CHO; SUN LI
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:US-6680335-B2
优先权日:1998-09-28
标题 :Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
发明人：TANG PENG CHO
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:WO-0056709-A1
优先权日:1999-03-24
标 题:Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
权利人:SUGEN INC; TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.