CAS: 218943-31-8; Boc-ß-Hoser(Bzl)-Oh

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tert-butyl N-{(1S)-[(benzyloxy)methyl]-3-diazo-2-oxopropyl}carbamate B°C-O-benzyl-L-serine 20H29NO7C20H29NO7 N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol(R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester (3R)-4-benzyloxy-3-[(tert-butoxycarbonyl)amino]butyric acid benzyl ester 3-HSer(OBn)-β3-HSer(OBn)-OMeB°C-β3-HSer(OBn)-β3-HSer(OBn)-OMe 3-HSer(OBn)-β3-HSer(OBn)-β3-HSer(OBn)-OMeB°C-β3-HSer(OBn)-β3-HSer(OBn)-β3-HSer(OBn)-OMe

N-(Tert-Butyloxycarbonyl)-O-Benzyl-L-Serinol置于4-二甲氨基吡啶,Potassium Fluoride,Sodium Tetrahydroborate,草酰氯,溶剂黄146,二甲基亚砜,Sodium Nitrite体系中,用 乙醚,乙醇,二氯甲烷,二甲基亚砜,异丙醇 用作溶剂,化学反应 32.67H,反应生成N-叔丁氧羰基-O-苄基-L-Beta-高丝氨酸
参考文献:A Mild Multistep Conversion Of N-Protected α-Amino Acids Into N-Protected β3-Amino Acids Utilizing The Nef Reaction
标题:A Mild Multistep Conversion Of N-Protected α-Amino Acids Into N-Protected β3-Amino Acids Utilizing The Nef Reaction
摘要:Current Methods Of Homologation Of Alpha-Amino Acids To Beta-Amino Acids Have Limitations. To Overcome These Shortfalls The Nef Reaction Has Been Utilized In The Multistep Synthesis Of Beta(3)-Amino Acids From Alpha-Amino Acids. In This Approach,N-Protected Amino Aldehydes,Easily Accessed From Alpha-Amino Acids,Were Transformed Into The N-Protected.Gamma-Amino Nitroalkanes. The Nef Reaction Was Then Used To Smoothly Convert The Nitroalkanes Into The Corresponding N-Protected Beta(3)-Amino Acids Without Notable Racemization.
Doi:10.1055/s-0032-1318344