CAS: 229975-97-7; Methyl ((5S,10S,11S,14S)-11-Benzyl-5-(Tert-Butyl)-10-Hydroxy-15,15-Dimethyl-3,6,13-Trioxo-8-(4-(Pyridin-2-yl)Benzyl)-2-Oxa-4,7,8,12-Tetraazahexadecan-14-yl)Carbamate Sulfate

上下游产品

atazanavir L-tert-Leucine methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate 1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-2-N-tert-butoxycarbonylamino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane

阿扎那韦置于硫酸体系中,用 乙醇 用作溶剂,以85.2%的收率获得阿扎那韦硫酸盐
参考文献:高效合成 Hiv 蛋白酶抑制剂 Bms-232632 的工艺研发
标题:高效合成 Hiv 蛋白酶抑制剂 Bms-232632 的工艺研发
摘要:为人类免疫缺陷病毒 (Hiv) 蛋白酶抑制剂 Bms-232632 1-[4-(Pyridin-2-yl)Phenyl]-5(S)-2,5-Bis{[n-(描述了甲氧羰基)-1-叔亮氨酸基]-氨基}-4(S)-羟基-6-苯基-2-氮杂己烷.合成中间体 N-1-(叔丁氧羰基)-N-2-[4-(吡啶-2-基)亚苄基]腙 (11) 的关键步骤是 Pd 介导的硼酸 9 与2-溴吡啶.开发了一种将腙 11 化学选择性还原为氨基甲酸肼 4 的有效程序.关键中间体 N-(叔丁氧羰基)-2(S)-氨基-1-苯基-3(R)-3,4-环氧-丁烷 (6) 由手性二醇 10 立体选择性制备.随后将 4 和 6 结合,然后与 N-甲氧基羰基-1-叔-亮氨酸偶联,以高收率提供游离碱 Bms-232632.
Doi:10.1021/op025504R

专利信息

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-2025017938-A1
优先权日:2023-06-20
标 题:Combination therapies of fasn inhibitors with thyroid hormone receptor agonists
发明人：O'FARRELL ANNE-MARIE; KEMBLE GEORGE; TSAI WEN-WEI
权利人:SAGIMET BIOSCIENCES INC
摘要:Therapeutic combinations of fatty acid synthesis modulators and thyroid hormone receptor agonists are provided. The combinations may be used to treat disorders including metabolic disorders and liver disorders, such as nonalcoholic steatohepatitis/metabolic dysfunction-associated steatohepatitis (NASH/MASH).

专利号:US-2023405016-A1
优先权日:2011-03-08
标题:Heterocyclic modulators of lipid synthesis