CAS: 27490-33-1; Hydroxymethyl Tributylstannane

相似化合物

994-89-8 66222-29-5 24850-33-7

上下游产品

dihydrogen peroxide tri-n-butyl-tin hydride tributylstannylmagnesium chloride formaldehyd 2-Hydroxymethylpyridine para-Chlorobenzyl alcohol benzyl alcohol 4-Methoxybenzyl alcohol

三正丁基氢锡置于正丁基锂,聚合甲醛,二异丙胺体系中,用 四氢呋喃 用作溶剂,以82%的收率获得(三丁基锡)甲醇
参考文献:溴和碘甲基三丁基锡的高效合成
标题:溴和碘甲基三丁基锡的高效合成
摘要:摘要 描述了一种以氢化三丁基锡为原料制备溴代三丁基锡和碘代三丁基锡的高效两步法.
Doi:10.1080/00397919408011706

专利信息

专利号:US-6172205-B1
优先权日:1997-12-11
标题 :Synthetic process toward total synthesis of eleutherobin and its analogues and uses thereof
发明人：DANISHEFSKY SAMUEL J; CHEN XIAO-TAO; GUTTERIDGE CLARE E; BHATTACHARYA SAMIT K; ZHOU BISHAN
权利人:TRUSTEES OF COLUMBIA IN THE CI
摘要:This invention provides a process for the preparation of a Eleutherobin derivative of the formula: n wherein R 1 is a hydrogen, ester, nitrile or C 2 H 4 —R wherein R 4 is a carbohydrate, an alcohol an amine, an amide, an alkyne, or, R 2 is a linear or branched alkyl moiety, R 3 is an ester, an amide, a carbamate, an acetal compound,an ether or a urethane, R 4 is a hydrogen or CH 2 ,position C 2 and C 3 is cis or trans,position C 8 is α or β and a compound is produced having the structures: n Additionally, this experiment provides a method for inhibiting growth of cancerous cells comprising contracting an amount of Eleutherobin derivative effective to inhibit the growth of said cells. Further provided is a method for treating cancer in a subject which comprises administering to the subject a therapeutically effective amount of the Eleutherobin derivative.

专利号:US-6194568-B1
优先权日:1998-07-13
标题:Process for synthesizing carbapenem intermediates
发明人：JENSEN MARK S; XIAO YI; YANG CHUNHUA; WELLS KENNETH M; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:The invention describes an improved process for synthesizing 1-beta-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention.The invention relates to the synthesis of a compound of formula 3:wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents H or methyl; and R5 represents a carboxy protecting group as well as the compounds made therein.

专利号:EP-1015452-B1
优先权日:1997-08-26
标题:Optionally protected 3-hydroxymethyl carbapenems and synthesis
发明人：CHUNG JOHN Y; LEAZER JOHNNIE L JR; YASUDA NOBUYOSHI; JENSEN MARK S; WELLS KENNETH M; YANG CHUNHUA
权利人:MERCK & CO INC
摘要:Novel crystalline carbapenem intermediate compounds of formula (I) wherein R1 represents CH3 or H; and P and P' independently represent H or a protecting group; and efficient process for synthesis thereof.

专利号:CN-114957258-A
优先权日:2021-02-25
标题 :Synthesis of a broad-spectrum serine β-lactamase inhibitor based on carbapenem structure and its application in the inhibition of drug-resistant bacteria

专利号:US-6346617-B1
优先权日:1997-08-26
标 题 :Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof
发明人：CHUNG JOHN Y; YASUDA NOBUYOSHI; LEAZER JR JOHNNIE L; JENSEN MARK S; WELLS KENNETH M; YANG CHUNHUA
权利人:MERCK & CO INC
摘要:A process for preparation of a compound of formula I:wherein:R1 represents CH3 or H; and P represents a protecting group;comprising reacting a compound of formula IV: wherein R1 and P and are defined above and R4 represents triflate or SO2F;in the presence of a catalyst and (R3)3SnCH2OP'', wherein each R3 represents C1-4 lower alkyl, and P'' represents H or a protecting group, to yield the compound of formula I.

专利号:EP-1935869-A1
优先权日:2000-10-02
标题:Retinoids for the treatment of emphysema
发明人：LAPIERRE JEAN MARC; ROTSTEIN MARC; SJOGREN ERIC BRIAN
权利人:HOFFMANN LA ROCHE
摘要:The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for such deseases and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.