CAS: 31301-51-6; 2-Chloro-5-Fluoropyridine

相似化合物

52208-50-1 17282-04-1 189281-48-9

上下游产品

CAS号5350-93-6 2-氯-5-氨基吡啶 | CAS号53939-30-3 5-溴-2-氯吡啶 | CAS号69045-79-0 2-氯-5-碘吡啶 | CAS号405230-93-5 2-氯-5-氟-3,4-吡啶二胺 | CAS号405230-90-2 2-氯-5-氟-3-硝基吡啶-4-胺 | CAS号89510-90-7 4-氨基-2氯-5-氟吡啶 | CAS号5350-93-6 2-氯-5-氨基吡啶 | CAS号21717-96-4 2-氨基-5-氟吡啶 | CAS号1334411-83-4 4-溴-2-(2,6-二氯苯基... | CAS号512171-81-2 5-氟-2-苯基吡啶 | CAS号405230-97-9 4-氯-7-氟-1H-咪唑并[... | CAS号405230-79-7 2-氯-5-氟吡啶1-氧化物 | CAS号405230-80-0 2-氯-5-氟-4-硝基吡啶-1-氧化物

5-溴-2-氯吡啶置于lithium Chloro-Isopropyl-Magnesium Chloride,N-氟代双苯磺酰胺体系中,用 四氢呋喃,1,4-二氧六环,二氯甲烷,十八氟十氢萘 用作溶剂,以75%的收率获得2-氯-5-氟吡啶
参考文献:功能化的芳基或杂芳基镁试剂通过亲电氟化大规模制备芳族氟化物
标题:功能化的芳基或杂芳基镁试剂通过亲电氟化大规模制备芳族氟化物
摘要:在氯化锂的存在下,由相应的溴化物或碘化物使用卤素-镁交换或直接插入镁制得的功能化芳基或杂芳基镁试剂,在混合溶剂中与n-氟苯磺酰亚胺(phso 2)2 Nf平稳反应(4 ∶1 Ch 2 Cl 2-全氟萘烷),以中等至非常好的收率获得相应的芳族氟化物. 芳烃-亲电取代-氟化-格氏试剂-杂芳族化合物
Doi:10.1055/s-0029-1218816

专利信息

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:US-9962690-B2
优先权日:2014-04-27
标题:N-substituted pyridiniophosphines, processes for their preparation and their use
发明人：ALCARAZO MANUEL; WILLE CHRISTIAN; TINNERMANN HENDRIK
权利人:STUDIENGESELLSCHAFT KOHLE MBH
摘要:The present invention deals with the synthesis and applications of new cationic compounds being useful as metal ligands. Specifically, N-alkyl/aryl substituted pyridiniophosphines are prepared and used as ligands for transition metals. The so-obtained metal complexes and their use as catalysts in chemical synthesis is also described. It also worth mentioning that N-alkyl/aryl pyridiniophosphines can be synthesized through a short, scalable and highly modular route.

专利号:US-11858943-B2
优先权日:2017-06-05
标题:Vasopressin receptor antagonists and products and methods related thereto
发明人：JONES ROBERT M; URBANO MARIANGELA; BRANDT GARY; HARDICK DAVID; KNIGHT CHRIS; TIERNEY JASON
权利人:NEUMORA THERAPEUTICS INC
摘要:Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:wherein A, B, G, R1, R1b, R1c, R2 and X are as defined herein.

专利号:CN-119371352-A
优先权日:2024-10-24
标题 :Synthesis method of 6-chloro-3-fluoro-2-methoxypyridine

专利号:CN-110092798-A
优先权日:2018-01-29
标题:A kind of heterocyclic compound as FGFR inhibitor and its synthesis method and application

专利号:CN-119613329-A
优先权日:2024-12-10
标 题:Synthesis method of compound 6-chloro-3-fluoro-2-iodopyridine