CAS: 3641-13-2; 5-Amino-4H-1,2,4-Triazole-3-Carboxylic Acid

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CAS号623-73-4 重氮乙酸乙酯 | CAS号3641-14-3 5-氨基-4H-[1,2,4]... | CAS号4928-87-4 1H-1,2,4-三氮唑-3-羧酸 | CAS号87253-62-1 5,7-二甲基-[1,2,4]... | CAS号674287-63-9 5-溴-1,2,4-三唑-3-甲酸 | CAS号63666-11-5 5-氨基-1H-1,2,4-三... | CAS号36033-56-4 5-碘-1H-1,2,4-三氮... | CAS号61-82-5 3-氨基-1,2,4-三唑 | CAS号21733-03-9 5-氯-1H-1,2,4-三唑-3-甲酸

Ethyl 2-(2-Carbamimidoylhydraziny)-2-Oxoacetic Acid置于水体系中,用 水 作为反应溶剂,化学反应 12.0H,以to Afford 5-Amino-1H-1,2,4-Triazole-3-Carboxylic Acid As A White Solid (1.1 G,63%)的收率获得产物5-氨基-1H-1,2,4-三氮唑-3-羧酸
参考文献:Heterocyclic Compounds For The Inhibition Of Pask
标题:Heterocyclic Compounds For The Inhibition Of Pask
摘要:本文披露了新的杂环化合物和组合物及其作为药物治疗疾病的应用.还提供了抑制人类或动物主体中pas激酶(pask)活性的方法,以治疗诸如糖尿病等疾病.

专利信息

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:WO-03042189-A1
优先权日:2001-11-15
标题:Process for producing 1-h-1,2,4-triazole-3-carboxylic acid ester
发明人：SHIMIZU SUMIO; NISHINO YUTAKA; YOSHIDA KAZUHIRO
权利人:SHIONOGI & CO; SHIMIZU SUMIO; NISHINO YUTAKA; YOSHIDA KAZUHIRO
摘要:A novel process for producing a 1-H-1,2,4-triazole-3-carboxylic acid ester (compound I-1). The compound (I-1) is obtained by: deaminating 5-amino-1,2,4-triazole-3-carboxylic acid (I-2), halogenating the deaminated acid to obtain an acid chloride, and esterifying it; or esterifying the compound (I-2) and then deaminating it; or subjecting ethyl-ß-formyloxalylamidrazone to ring closure with the aid of a trialkyl orthoester and an acid. The compound (I-1) is an intermediate for the synthesis of a compound (I-13) (1-(substituted furan)-3-hydroxy-3-(1,2,4-triazole)propenone), which has anti-HIV activity. The process is hence extremely useful.

专利号:US-6090912-A
优先权日:1993-05-27
标 题:Topologically segregated, encoded solid phase libraries comprising linkers having an enzymatically susceptible bond
发明人：LEBL MICHAL; LAM KIT S; SALMON SYDNEY E; KRCHNAK VICTOR; SEPETOV NIKOLAI; KOCIS PETER
权利人:SELECTIDE CORP
摘要:The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.

专利号:US-5840485-A
优先权日:1993-05-27
标题 :Topologically segregated, encoded solid phase libraries
发明人：LEBL MICHAL; LAM KIT S; SALMON SYDNEY E; KRCHNAK VICTOR; SEPETOV NIKOLAI; KOCIS PETER
权利人:SELECTIDE CORP
摘要:The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.

专利号:CN-109988118-B
优先权日:2017-12-29
标 题 :A kind of heterocyclic azo compound and its synthesis method and application