CAS: 481-85-6; 2-Methylnaphthalene-1,4-Diol

上下游产品

CAS号58-27-5 维生素K3 | CAS号1515-76-0 1-乙酰氧基-1,3-丁二烯 | CAS号553-97-9 甲基苯醌 | CAS号881-03-8 2-甲基-1-硝基萘 | CAS号95-71-6 鹿蹄草素 | CAS号95-48-7 邻甲酚 | CAS号67597-84-6 2-Methyl-1,4-na... | CAS号53772-19-3 2-methyl-1,4-di... | CAS号39055-47-5 2-bromo-3-methy... | CAS号21564-92-1 2,3-Dimethyltetralin | CAS号58-27-5 维生素K3 | CAS号139553-29-0 2,3-dihydroxy-2... | CAS号26271-55-6 3,3'-Dimethyl-2... | CAS号2197-57-1 1,4-Naphthalene... | CAS号5519-38-0 1-methylbenzo[f... | CAS号78265-13-1 1,4-二甲氧基-2-萘酸 | CAS号84-80-0 维生素 K1 | CAS号84-81-1 維生素K2(30)

甲萘醌置于sodium Dithionite体系中,用 乙醚 作为反应溶剂,化学反应生成 1,4-二羟基-2-甲基萘
参考文献:在ω-末端侧链引入烷基化苯基的新型维生素k衍生物的合成及其神经分化活性的评价
标题:在ω-末端侧链引入烷基化苯基的新型维生素k衍生物的合成及其神经分化活性的评价
摘要:维生素k是γ-谷氨酰羧化酶必不可少的辅助因子,与凝血和骨形成有关.menaquinone-4是维生素k的同系物之一,是在体内生物合成的,具有多种生物活性,例如是甾体和异种生物受体的配体,保护神经元细胞免受氧化应激等.从这一背景出发,我们集中研究了甲萘醌在祖细胞向神经元细胞分化中的作用,并合成了具有ω-末端侧链修饰的新型维生素k衍生物.我们在这里报告了新的维生素k类似物,它在ω-末端侧链上引入了烷基化的苯基.与对照相比,这些化合物表现出有效的分化活性.
DOI:10.1016/j.Bmcl.2017.09.038

专利信息

专利号:US-11912654-B2
优先权日:2021-09-03
标 题:Process for stereospecific synthesis of vitamin K2 and its novel intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; SHAH ASHWIN; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:WO-2023031841-A1
优先权日:2021-09-03
标题:A process for the stereospecific synthesis of vitamin k2 and its intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:WO-2024013633-A1
优先权日:2022-07-11
标 题 :Process for the synthesis of vitamin k2
发明人：SHASTRI MAYANK; BAIKAR MRUNALI H; VORA PARIN K; BNS RAJU
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.

专利号:US-9464021-B2
优先权日:2013-11-01
标题 :Method of preparation of stereospecific quinone derivatives
发明人：MEHTA DILIP S; MOHAN PRIYA; SHASTRI MAYANK; REID TED
权利人:MEHTA DILIP S; MOHAN PRIYA; SHASTRI MAYANK; REID TED
摘要:The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)â€? to overcome isomerization generated due to delocalization of allyliccarbanion on the Ï€-electron cloud of an allylic systems by the conventional synthesis.

专利号:US-12168649-B2
优先权日:2018-08-17
标 题 :Synthesis of chromanol and 2-methyl-1,4-naphthoquinone derivatives
发明人：WEINGARTEN MELANIE; SIEGEL WOLFGANG; PUHL MICHAEL
权利人:BASF SE
摘要:The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.