CAS: 5105-78-2; N-Cbz-4-Aminobutanoic Acid

上下游产品

CAS号501-53-1 氯甲酸苄酯 | CAS号56-12-2 4-氨基丁酸 | CAS号67706-63-2 methyl 4-(pheny... | CAS号5105-79-3 2-Methyl-2-prop... | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号1885-14-9 氯甲酸苯酯 | CAS号361145-43-9 γ-(benzyloxycar... | CAS号14468-80-5 1-Z-2-吡咯烷酮 | CAS号28493-86-9 Butanoicacid, 4... | CAS号61995-20-8 1-N-Cbz-3-哌啶酮 | CAS号16644-57-8 Carbamic acid,N... | CAS号67706-63-2 methyl 4-(pheny... | CAS号90139-74-5 4-[4-[4-(phenyl... | CAS号98008-66-3 4-{[(苄氧基)羰基](甲基... | CAS号5105-79-3 2-Methyl-2-prop...

1-Cbz-吡咯烷置于ruthenium(Iv) Oxide,Sodium Periodate体系中,用 叔丁醇 作为反应溶剂,化学反应 3.0H,反应生成 N-苄氧羰基-4-氨基丁酸
参考文献:单层方法用四氧化钌氧化环状n-酰基胺:形成ω-氨基酸
标题:单层方法用四氧化钌氧化环状n-酰基胺:形成ω-氨基酸
摘要:含叔丁醇作为单层系统的10%naio 4水溶液对环n-酰基胺的四氧化钌氧化导致环内c-N键断裂,从而提供ω-氨基酸,几乎是唯一的产物.非常好的收率,同时使用naio 4水溶液和乙酸乙酯在双层下进行类似的氧化,得到n-酰基内酰胺.
DOI:10.1016/j.Tetlet.2008.02.127

专利信息

专利号:US-7351852-B2
优先权日:2000-09-05
标题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates therof, and processes for productions of them
发明人：IKEDA HISAFUMI; SAITO ISAO; NAKAMURA YUSHIN
权利人:CREDIA JAPAN CO LTD
摘要:A process for amino acid derivatives shown by the below general formula (I): n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II):n n n(wherein R 1 has the same meaning as described above, and R 2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV):n n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.

专利号:US-7417035-B2
优先权日:1998-11-19
标 题:Phospholipid derivatives of non-steroidal anti-inflammatory drugs
发明人：KOZAK ALEXANDER; SHAPIRO ISRAEL
权利人:DPHARM LTD
摘要:Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and the use thereof for the treatment of diseases and disorders related to inflammatory conditions.

专利号:US-2004039224-A1
优先权日:2000-09-05
标 题 :T-butoxycarbonylaminoethylamine for the synthesis of pna monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them

专利号:US-2008167491-A1
优先权日:2000-05-09
标题:T-butoxycarbonylaminoethylamine for the Synthesis of PNA Monomer Units, Amino Acid Derivatives, Intermediates Thereof, and Processes for Productions of Them

专利号:US-2005187402-A1
优先权日:2000-09-05
标 题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them

专利号:US-4218404-A
优先权日:1976-05-06
标 题:ω-Aminocarboxylic acid amides
发明人：FEUER LASZLO; FURKA ARPAD; HERCSEL JOLAN; HORVATH ANIKO; SEBESTYEN FERENC
权利人:CHINOIN GYOGYSZER ES VEGYESZET
摘要:The invention relates to novel omega -aminocarboxylic acid amides having the formula (I) (I) wherein A is -SO2OH or -OPO(OH)2, R1 is hydrogen, an acyl group, such as benzoyl, arylsulfonyl, alkoxycarbonyl, cycloalkoxycarbonyl or aralkoxycarbonyl group or an aralkoxycarbonyl group having a halogen, alkoxy, nitro, phenylazo or alkoxyphenylazo substituent, alkyl-substituted aryloxycarbonyl or carbonyl, R2 is hydrogen or a carbonyl group, with the proviso that when R1 and R2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is -SO2OH and R1 is an acyl group such as benzoyl, aryl sulfonyl, alkoxy-carbonyl, cycloalkoxycarbonyl or aryloxycarbonyl group or an aralkoxy carbonyl group having a halogen, alkoxy, nitro, phenylozo or alkoxyphenylazo substituent or an alkyl-substituted aryloxycarbonyl group or carbonyl group, R2 is hydrogen or a carbonyl group, with the proviso that when R1 and R2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is -O-P-O(OH)2 and n is equal to 2 or 3, and salts of the above compounds, furthermore to a process for the preparation thereof. The novel compounds according to the invention possess valuable pharmacological effects in reducing blood sugar levels or can be applied as intermediate in the synthesis of biologically active compounds.