CAS: 5351-69-9; N-Phenylhydrazinecarbothioamide

该化合物是一种有机化合物,其特点是其硫磺酸盐结构,其中包括一个附于硫磺氨基甲氨基甲酸酯混合物氮原子的联苯组,通常看起来像一种白色的脱白晶晶体,以其在医学化学中的潜在用途而著称,特别是作为各种生物活性化合物的前体;该化合物在乙醇和二甲基硫氧化物等有机溶剂中溶解,但水中的溶解性有限. 4-苯基甲氨基甲酸酯展示可能包括抗微生物和抗癌活动的特性,使其对药物研究感兴趣,其再活性受硫代氨基甲酸酯功能组的存在影响,该功能组可以参与各种化学反应,包括凝聚和与金属离子的协调.在处理该化合物时,应当注意安全防范,因为如果浸入或吸入吸入,可能会对健康构成风险.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

phenyl isothi°Cyanate N,N-diphenylthiourea 3-phenylrhodanine carbon disulfide (E)-N-phenyl-2-(pyridin-4-ylmethylene)hydrazine-1-carbothioamide (E)-N-phenyl-2-(pyridin-3-ylmethylene)hydrazine-1-carbothioamide 1-phenylthiosemicarbazonefuran-2-carbaldehyde N1-phenylthiosemicarbazone 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-phenylhydrazinecarbothioamide

合成工艺路线路线简述

  • 合成目标产物 4-Phenyl-3-Thiosemicarbazide 主要起始原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
  • (文献来源)合成步骤主要原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
N-Phenyldithiocarbamic Acid置于sodium Monochloroacetic Acid,一水合肼体系中,用 乙醇,水 作为反应溶剂,化学反应 4.0H,反应生成 4-苯基-3-硫代氨基脲
参考文献:微波辐射下无溶剂合成吲哚基缩氨基硫脲
标题:微波辐射下无溶剂合成吲哚基缩氨基硫脲
摘要:开发了一种快速,高效且环保的方法,用于在微波辅助无溶剂条件下以氧化铝为固体载体合成吲哚-3-甲醛缩氨基硫脲.与常规加热方法相比,该方法得到的目标产物收率非常好.
DOI:10.3184/030823410X12628833270368

专利信息


专利号:WO-2016111658-A1
优先权日:2015-01-07
标 题:Synthesis of thiosemicarbazone derivatives comprising sulphonamide group with potential anticonvulsant activity
发明人:IYIDOGAN AYSEGUL; EMRE EMINE ELCIN; TOPALFAKIOGÄžLU RAHIME BETÜL; KAYMAKÇIOÄžLU BEDIA; ARICIOÄžLU FEYZA
权利人:IYIDOGAN AYSEGUL; EMRE EMINE ELCIN
摘要:The present invention relates to the synthesis method of thiosemicarbazone derivatives comprising sulphonamide group and having high anticonvulsant/antiepileptic activity.

专利号:US-10975048-B2
优先权日:2015-12-14
标题 :Composition of 1,3,4-selenadiazole containing compounds with pharmacological activity
发明人:RUAN BENFANG HELEN; RUAN JENNIFER JIN
权利人:HANGZHOU JENNIFER BIOTECH CO LTD
摘要:The invention belongs to the field of biomedical research involving the 1,3,4-selenyldiazo derivatives that have cell protective activity. Because there are not so many heterocyclic selenium compounds, we synthesized a new type of selenium analog of BPTES. As the isoacceptor of BPTES, the compounds have antitumor activity, anti-oxidation and cell protection function. Currently many drugs contain the thiodiazo motif, so synthesis of selenyldiazo functional group could further optimize these drugs and are important in new drug development and application.

专利号:CN-112250661-A
优先权日:2020-11-18
标题 :A kind of method for catalyzing synthesis of lactide

专利号:US-7045503-B1
优先权日:1996-07-12
标 题 :Radiometal-binding peptide analogues
发明人:MCBRIDE WILLIAM J; GRIFFITHS GARY L
权利人:IMMUNOMEDICS INC
摘要:Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand introduction or cyclization can be conducted at any point during the synthesis of the peptide. Such peptide derivatives are readily labeled with radiometals, such as isotopes of rhenium or technetium, while retaining their ability to tightly bind specific peptide receptors.

专利号:CN-112250661-B
优先权日:2020-11-18
标题:A kind of method for catalyzing synthesis of lactide

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人:RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
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主要参考文献

[参考文献]: Derya Kara, Et Al. Determination Of Trace Heavy Metals In Soil And Sediments By Atomic Spectrometry Following Preconcentration With Schiff Bases On Amberlite Xad-4. J Hazard Mater. 2009 Jun 15;165(1-3):1165-9.

合成参考文献


参考文献:10.1107/s1600536811008920
摘要:Dzulkifli NN, Farina Y, Yamin BM, Baba I, Tiekink ER. 3-[(E)-(4-Chloro-benzyl-idene)amino]-1-phenyl-thio-urea. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o872.
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