CAS: 57-08-9; 6-Acetamidohexanoic Acid

该化合物是一种多用途有机化合物,其成分包括乙酰胺和碳本酸功能组,使它成为有机合成和制药应用中有价值的中间体.其结构允许进一步衍生,能够生产特殊化合物,如peptidemimimics或聚合物前体.该化合物在普通有机溶剂中的稳定性和溶性有利于其在受控反应中的使用.此外,它与氨化联成反应的兼容性使得它适合于建造复杂的分子结构.该化合物在药用化学中对于开发定向治疗或生物活性分子特别有用.

结构式图片

相似化合物

2014-58-6 3025-96-5 20766-85-2

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

N-acetylcaprolactam acetic anhydride 6-aminohexanoic acid acetic acid 2-methyl-4,5,6,7-tetrahydro-3H-azepine caprolactam 6-aminohexanoic acid ethyl 6-(acetylamino)hexanoate

合成工艺路线路线简述

    6-Acetamidogulonic Acid 以5的收率获得产物醋氨己酸
    参考文献:Production Of Caprolactam From Carbohydrate-Containing Materials
    标题:Production Of Caprolactam From Carbohydrate-Containing Materials
    摘要:本发明通常涉及利用化学催化氧化和还原反应将葡萄糖转化为己内酰胺的过程.本发明还包括通过酰胺聚羟基酸产物和酰胺己酸或其衍生物将葡萄糖转化为己内酰胺的过程.本发明还包括催化氧化酰胺聚醇为酰胺聚羟基酸或其衍生物的过程,以及催化氢解氨基或酰胺聚羟基酸或其衍生物为氨基或酰胺己酸产品的过程.然后,氨基或酰胺己酸产品可以转化为己内酰胺.本发明还包括由这些过程产生的产品以及由这些产品可生产的产品.

    海关参考信息

    专利信息


    专利号:US-5135925-A
    优先权日:1990-04-06
    标题 :Use of zinc acexamate in the prophylaxis of gastropathy induced by non-steroidal anti-inflammatory drugs
    发明人:VINAS ANTONIO B
    权利人:VINAS LAB
    摘要:Zinc acexamate acts by increasing the synthesis of mucus, reinforces the mucous barrier, improves the microcirculation and increases the synthesis of prostaglandins in the gastric mucous membrane, whereby it is effective in the treatment of said gastropathy, contrary to the results obtained with antiacids or antisecretory agents.

    专利号:EP-0369088-B1
    优先权日:1988-11-14
    标题 :Use of zinc acexamate in the prophylaxis of gastropathy induced by non-steroidal anti-inflammatory drugs
    摘要:Zinc acexamate acts by increasing the synthesis of mucus, reinforces the mucous barrier, improves the microcirculation and increases the synthesis of prostaglandins in the gastric mucous membrane, whereby it is effective in the treatment of said gastropathy, contrary to the results obtained with antiacids or antisecretory agents.

    专利号:US-2024287041-A1
    优先权日:2021-05-20
    标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
    发明人:BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
    权利人:KARYOPHARM THERAPEUTICS INC
    摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

    专利号:US-6387238-B1
    优先权日:1999-08-05
    标题:Electrolytic synthesis of peracetic acid
    发明人:MERK TOM L; MALCHESKY PAUL S; LIU CHUNG-CHIUN
    权利人:STERIS INC
    摘要:An electrolysis unit (10, 210, 310) has an anode (16, 216,316) and a gas diffusion cathode (18, 218, 318). Air is fed to the cathode (18, 218) to generate peroxide species, such as hydrogen peroxide, peroxide ions, or peroxide radicals by electrolysis of oxygenated water. A peracetic acid precursor, such as acetyl salicylic acid, reacts with the peroxide to form peracetic acid. An ion selective barrier (20, 220) optionally separates the unit into two chambers, an anodic chamber (12, 212) and a cathodic chamber (14, 214). By selecting either a proton permeable membrane or an anion exchange membrane for the barrier, the peracetic acid may be formed in either an alkaline electrolyte in the cathodic chamber or in an acid electrolyte in the anode chamber, respectively.

    专利号:US-9994558-B2
    优先权日:2013-09-20
    标题 :Multicyclic compounds and methods of using same
    发明人:BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
    权利人:KARYOPHARM THERAPEUTICS INC
    摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

    专利号:WO-2006097348-A1
    优先权日:2005-03-15
    标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
    发明人:CALS-GRIERSON MARIE-MADELEINE
    权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
    摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .
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    主要参考文献


    1: Reis AM, Silva R, Pignatelli J. Allergic contact dermatitis to acexamic acid. Contact Dermatitis. 2008 Apr;58(4):241-2. doi: 10.1111/j.1600-0536.2007.01258.x. French. French. Romanian. Romanian. French. French.
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